Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

T-cells are causally involved in the pathogenesis of inflammatory bowel disease (IBD). The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) regulates T-cell proliferation and survival. We show in this report that IDO mRNA is markedly induced in lesional colonic biopsies of IBD patien...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 113(2004), 1 vom: 15. Okt., Seite 47-55
1. Verfasser: Wolf, Anna Maria (VerfasserIn)
Weitere Verfasser: Wolf, Dominik, Rumpold, Holger, Moschen, Alexander R, Kaser, Arthur, Obrist, Peter, Fuchs, Dietmar, Brandacher, Gerald, Winkler, Christiane, Geboes, Karel, Rutgeerts, Paul, Tilg, Herbert
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Gastrointestinal Agents Histocompatibility Antigens Class II IL3RA protein, human Indoleamine-Pyrrole 2,3,-Dioxygenase Interleukin-3 Receptor alpha Subunit RNA, Messenger Receptors, Interleukin-3 mehr... Tumor Necrosis Factor-alpha Infliximab B72HH48FLU Tryptophan Oxygenase EC 1.13.11.11