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01000naa a22002652 4500 |
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NLM148943241 |
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DE-627 |
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20231223050657.0 |
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tu |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0497.xml
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|a (DE-627)NLM148943241
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|a (NLM)15207786
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Takeda, Satoshi
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Hemagglutinating virus of Japan protein is efficient for induction of CD4+ T-cell response by a hepatitis B core particle-based HIV vaccine
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 19.08.2004
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| 500 |
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|a Date Revised 21.11.2008
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a By using the hepatitis B core (HBc) protein gene as a carrier, HIV-1 env V3 gene was inserted into the carrier gene, and the HIV gene was expressed inside a chimeric HIV-HBc particle (HIV-HBc), which was a unique candidate for induction of HIV-specific CTL activity. This was seen significantly in mice without the need of an adjuvant, because other responses specific for the HIV peptide such as T-cell proliferation and antibody production were not induced. However, when hemagglutinating virus of Japan (HVJ) protein was incorporated into an anionic liposome containing HIV peptide (HIV-HVJ-liposome) and was used as a booster immunization in HIV-HBc primed animals, the HIV-specific T-cell response and enhanced CTL activity were clearly induced in consecutively immunized animals. Furthermore, the HIV-specific humoral immune response was also induced and a neutralization activity was detected in the immune sera. Thus, when an HIV peptide antigen is expressed inside the virus like a particle of HBc, it can induce both cellular and humoral immunities when an HVJ-HIV-liposome, but not an HIV-liposome, is inoculated as the booster antigen. The HVJ-stimulated splenocytes secreted IL-18 and IL-12 to synergistically enhance the secretion of IFN-gamma in vitro. These findings suggest that the HVJ protein is effective at inducing the HIV-specific immunities, if used as part of a booster antigen in the consecutive immunization regimen
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a AIDS Vaccines
|2 NLM
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| 650 |
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7 |
|a HIV Antibodies
|2 NLM
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| 650 |
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7 |
|a HIV Envelope Protein gp120
|2 NLM
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| 650 |
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7 |
|a Hepatitis B Core Antigens
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Liposomes
|2 NLM
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| 650 |
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7 |
|a Recombinant Fusion Proteins
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Shiosaki, Kouichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kaneda, Yasufumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nakasatomi, Tetsuya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yoshizaki, Hitomi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Someya, Kenji
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Konno, Yusuke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eda, Yasuyuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kino, Youichirou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamamoto, Naoki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Honda, Mitsuo
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 112(2004), 1 vom: 16. Juli, Seite 92-105
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:112
|g year:2004
|g number:1
|g day:16
|g month:07
|g pages:92-105
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
|
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|a GBV_ILN_350
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| 951 |
|
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|a AR
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| 952 |
|
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|d 112
|j 2004
|e 1
|b 16
|c 07
|h 92-105
|