Clinical significance of serum S-100B protein in severe cerebral injury
OBJECTIVE: To investigate the value of S-100B protein as a biology marker in diagnosis and prognostic after severe cerebral injury
| Veröffentlicht in: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 16(2004), 4 vom: 06. Apr., Seite 221-2 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , |
| Format: | Aufsatz |
| Sprache: | Chinese |
| Veröffentlicht: |
2004
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| Zugriff auf das übergeordnete Werk: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue |
| Schlagworte: | English Abstract Journal Article Research Support, Non-U.S. Gov't Nerve Growth Factors S100 Calcium Binding Protein beta Subunit S100 Proteins |
| Zusammenfassung: | OBJECTIVE: To investigate the value of S-100B protein as a biology marker in diagnosis and prognostic after severe cerebral injury METHODS: Sixty-six patients with severe head injury (Glasgow coma scale score (GCS)<or=8) were included in this study, venous blood samples for S-100B protein were obtained as soon as possible after admission and every 24 hours thereafter for a maximum of 3-7 consecutive days. Serum levels of S-100B protein were compared with outcome (Glasgow outcome scale score, GOS) after 6 months RESULTS: Of 66 patients, 25 patients died, mutilation in 22 patients, 19 patients had a good outcome. Patients who died had significantly higher serum S-100B values compared with those who survived (median 2.60 microg/L vs. 0.55 microg/L, P<0.001), 14 of 25 patients who died had peak S-100B values of 2.00 microg/L or higher, compared with 4 of 41 surviving patients (P<0.005) CONCLUSION: S-100B protein has a reliable value in diagnosis and prognostic after severe head injury |
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| Beschreibung: | Date Completed 07.10.2004 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
| ISSN: | 1003-0603 |