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231223s2003 xx ||||| 00| ||eng c |
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|a pubmed25n0475.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rørvik, K A
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Synergistic effects of dietary iron and omega-3 fatty acid levels on survival of farmed Atlantic salmon, Salmo salar L., during natural outbreaks of furunculosis and cold water vibriosis
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| 264 |
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|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.11.2003
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|a Date Revised 30.09.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a The present study demonstrates that farmed Atlantic salmon, Salmo salar, health is positively and significantly affected by synergistic effects between very long-chain polyunsaturated fatty acids of the n-3 family eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and iron, where positive effects of high dietary levels of EPA/DHA are enhanced when combined with low levels of iron. Based on cumulative mortalities in the different experimental groups, relative percentage of survival (RPS) for the high EPA/DHA-low iron group was 70% during an outbreak of furunculosis and 96% during an outbreak of cold water vibriosis compared with the controls. A non-additive effect between EPA/DHA and iron was confirmed by statistical analyses that revealed a significant effect of EPA/DHA alone and an interaction of iron with EPA/DHA. Liver cell cultures treated with EPA/DHA revealed that the synergistic effect could be related to an EPA/DHA dependent regulation of mRNA for proteins important for transport (transferrin) and storage (ferritin) of iron in the salmon. In keeping with this finding, the transcriptional down-regulation of iron metabolism in vitro was reflected in decreased in vivo iron stores with increasing levels of dietary EPA/DHA. Hence, to avoid overloading of the iron transport/storage-systems resulting in increased susceptibility to bacterial infections, high levels of dietary EPA/DHA should be accompanied by low levels of dietary iron
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| 650 |
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|a Journal Article
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7 |
|a Fatty Acids, Omega-3
|2 NLM
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| 650 |
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|a Iron, Dietary
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 650 |
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|a Transferrin
|2 NLM
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| 650 |
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7 |
|a Docosahexaenoic Acids
|2 NLM
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| 650 |
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7 |
|a 25167-62-8
|2 NLM
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| 650 |
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7 |
|a Ferritins
|2 NLM
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| 650 |
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7 |
|a 9007-73-2
|2 NLM
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| 650 |
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7 |
|a Eicosapentaenoic Acid
|2 NLM
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| 650 |
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7 |
|a AAN7QOV9EA
|2 NLM
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| 700 |
1 |
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|a Dehli, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thomassen, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ruyter, B
|e verfasserin
|4 aut
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| 700 |
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|a Steien, S H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Salte, R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 26(2003), 8 vom: 20. Aug., Seite 477-85
|w (DE-627)NLM098166034
|x 0140-7775
|7 nnns
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| 773 |
1 |
8 |
|g volume:26
|g year:2003
|g number:8
|g day:20
|g month:08
|g pages:477-85
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| 952 |
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|d 26
|j 2003
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|h 477-85
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