The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components implications for T-cell activation

The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components : implications for T-cell activation

Lipid rafts play an important role in signal integration and cellular activation by the T-cell antigen receptor (TCR). We demonstrate that flotillin-1 and flotillin-2 are important structural raft components, which redistribute to the site of TCR engagement. An antibody to flotillin-1 was able to im...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 2 vom: 15. Aug., Seite 138-51
1. Verfasser: Slaughter, Ndaisha (VerfasserIn)
Weitere Verfasser: Laux, Isett, Tu, Xiaolin, Whitelegge, Julian, Zhu, Xiaoming, Effros, Rita, Bickel, Perry, Nel, Andre
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Adaptor Proteins, Signal Transducing CD28 Antigens CD3 Complex Carrier Proteins Glycoproteins LAT protein, human Lat protein, mouse mehr... Membrane Proteins PSAP protein, human Phosphoproteins Psap protein, mouse Receptors, Antigen, T-Cell Saposins Sh2d2a protein, mouse Sphingolipid Activator Proteins flotillins Lymphocyte Specific Protein Tyrosine Kinase p56(lck) EC 2.7.10.2