Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide expression of canonical variable regions and their variants in vaccinated infants

Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide : expression of canonical variable regions and their variants in vaccinated infants

A structurally conserved antibody combining site, encoded by the IGH V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune response to the Haemophilus influenzae type b (Hib) capsular polysaccharide (PS). This site has been elevated to canonical status based upon its re...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 2 vom: 15. Aug., Seite 119-27
1. Verfasser: Lucas, Alexander H (VerfasserIn)
Weitere Verfasser: McLean, Gary R, Reason, Donald C, O'Connor, Adam P, Felton, Mistique C, Moulton, Karen D
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Antibodies, Anti-Idiotypic Antibodies, Bacterial Bacterial Proteins Haemophilus Vaccines Immunoglobulin Fab Fragments Immunoglobulin Heavy Chains Immunoglobulin Light Chains mehr... Immunoglobulin Variable Region Polysaccharides, Bacterial Vaccines, Synthetic HibTITER protein, Haemophilus influenzae 126161-67-9