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01000caa a22002652 4500 |
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NLM125067747 |
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DE-627 |
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20250204001759.0 |
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tu |
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231222s2003 xx ||||| 00| ||eng c |
| 028 |
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2 |
|a pubmed25n0417.xml
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|a (DE-627)NLM125067747
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|a (NLM)12738250
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lichterfeld, Mathias
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 17.06.2003
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|a Date Revised 07.11.2019
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a DC-SIGNR is a C-type lectin that functions as a transreceptor for HIV-1. The exon 4 of the DC-SIGNR gene comprises a variable number of 69-bp tandem repeats, encoding for parts of the extracellular protein domain. Here, we analyzed the relevance of this gene polymorphism for the interindividual transmission of HIV-1 and the progression to AIDS. A cross-sectional comparison between HIV-1-infected patients (n = 391) and healthy volunteers (n = 134) did not reveal significant differences with regard to the DC-SIGNR allele distribution. Moreover, DC-SIGNR allele frequencies were similar in slowly progressing HIV patients (n = 31) and patients who rapidly progressed to AIDS (n = 46). Additionally, in a cohort of 149 newly HIV-infected patients, no relationship was found between HIV set point viremia and DC-SIGNR genotypes. Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a CLEC4M protein, human
|2 NLM
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| 650 |
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7 |
|a Cell Adhesion Molecules
|2 NLM
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| 650 |
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7 |
|a DNA, Viral
|2 NLM
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| 650 |
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7 |
|a Lectins, C-Type
|2 NLM
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| 650 |
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7 |
|a Receptors, Cell Surface
|2 NLM
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| 700 |
1 |
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|a Nischalke, Hans Dieter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van Lunzen, Jan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Söhne, Jennifer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schmeisser, Norbert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Woitas, Rainer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sauerbruch, Tilman
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rockstroh, Jürgen K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Spengler, Ulrich
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 107(2003), 1 vom: 01. Apr., Seite 55-9
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
8 |
|g volume:107
|g year:2003
|g number:1
|g day:01
|g month:04
|g pages:55-9
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 107
|j 2003
|e 1
|b 01
|c 04
|h 55-9
|