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01000naa a22002652 4500 |
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NLM120261146 |
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DE-627 |
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20231222190516.0 |
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tu |
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231222s2002 xx ||||| 00| ||eng c |
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|a (NLM)12165277
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Radeke, Heinfried H
|e verfasserin
|4 aut
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| 245 |
1 |
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|a CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury
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|c 2002
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 10.10.2002
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|a Date Revised 09.04.2022
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|a published: Print
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|a Citation Status MEDLINE
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|a To investigate, whether T lymphocytes alone are sufficient to induce glomerulonephritis, a model in SCID mice was developed. Conditions for the generation and exclusive glomerular targeting of crosslinked ovalbumin (OVA) polymers and a series of OVA-specific T-cell clones and lines were established. Only a well-defined subfraction of OVA polymers exclusively targeted to the glomerular mesangium without causing local alteration in the absence of IgG. From numerous T-cell preparations spanning different Th-1/-2 profiles one T-helper cell clone characterized by ELISPOT assay as pure Th-1 (IFN-gamma and IL-2) induced nephritislike pathology. Histological examination at days 1, 2, 5, and 21 showed major infiltrates in proximal tubular regions (PTR) at day 5 accompanied by significant proteinuria. No injury was observed after deposition of irrelevant antigen or injection of other T-cell preparations. Detailed histological analysis revealed that Th-1 cell numbers peaked early in glomeruli (2.1 +/- 0.6 vs 0/gcs). Macrophages, however, were hardly detectable in glomeruli (0.5 +/- 0.3/gcs) at this time, while they formed the major constituent of the PTR infiltrates at day 5 (83 +/- 1). These data in a new SCID nephritis model indicate that memory Th-1 cells together with localized antigen presenting cells trigger nephritis
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens
|2 NLM
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| 650 |
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7 |
|a Ovalbumin
|2 NLM
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| 650 |
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7 |
|a 9006-59-1
|2 NLM
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| 700 |
1 |
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|a Tschernig, Thomas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Karulin, Alexey
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schumm, Georg
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Emancipator, Steve N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Resch, Klaus
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tary-Lehmann, Magdalena
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 104(2002), 2 vom: 06. Aug., Seite 161-73
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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|g volume:104
|g year:2002
|g number:2
|g day:06
|g month:08
|g pages:161-73
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