CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury

CD4+ T cells recognizing specific antigen deposited in glomeruli cause glomerulonephritis-like kidney injury

To investigate, whether T lymphocytes alone are sufficient to induce glomerulonephritis, a model in SCID mice was developed. Conditions for the generation and exclusive glomerular targeting of crosslinked ovalbumin (OVA) polymers and a series of OVA-specific T-cell clones and lines were established....

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 104(2002), 2 vom: 06. Aug., Seite 161-73
1. Verfasser: Radeke, Heinfried H (VerfasserIn)
Weitere Verfasser: Tschernig, Thomas, Karulin, Alexey, Schumm, Georg, Emancipator, Steve N, Resch, Klaus, Tary-Lehmann, Magdalena
Format: Aufsatz
Sprache:English
Veröffentlicht: 2002
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens Ovalbumin 9006-59-1