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01000naa a22002652 4500 |
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NLM117747955 |
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DE-627 |
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20231222181217.0 |
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tu |
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231222s2002 xx ||||| 00| ||eng c |
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|a pubmed24n0393.xml
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|a (DE-627)NLM117747955
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|a (NLM)11890717
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Makino, Yasuhiko
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Impaired T cell function in RANTES-deficient mice
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| 264 |
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1 |
|c 2002
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 17.04.2002
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| 500 |
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|a Date Revised 21.11.2008
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| 500 |
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to participate in many aspects of the immune response. To evaluate the biological roles of RANTES in vivo, we generated RANTES-deficient (-/-) mice and characterized their T cell function. In cutaneous delayed-type hypersensitivity assays, a 50% reduction in ear and footpad swelling was seen in -/- mice compared to +/+ mice. In vitro, polyclonal and antigen-specific T cell proliferation was decreased. Quantitative analysis using the fluorescent dye carboxy-fluorescein succinimidyl ester revealed that this proliferative defect was due both to fewer antigen-reactive T cells and to a reduction in the capacity of these cells to proliferate. In addition, IFN-gamma and IL-2 production by the -/- T cells was dramatically decreased. Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Chemokine CCL5
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Cook, Donald N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Smithies, Oliver
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hwang, Olivia Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Neilson, Eric G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Turka, Laurence A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sato, Hiroshi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wells, Andrew D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Danoff, Theodore M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 102(2002), 3 vom: 22. März, Seite 302-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:102
|g year:2002
|g number:3
|g day:22
|g month:03
|g pages:302-9
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| 912 |
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|a AR
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|d 102
|j 2002
|e 3
|b 22
|c 03
|h 302-9
|