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01000naa a22002652 4500 |
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NLM103025529 |
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DE-627 |
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20231222125505.0 |
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tu |
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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed24n0344.xml
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|a (DE-627)NLM103025529
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|a (NLM)10370375
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Weintraub, J P
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Ectopic expression of B7-1 (CD80) on T lymphocytes in autoimmune lpr and gld mice
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| 264 |
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1 |
|c 1999
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 25.06.1999
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| 500 |
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|a Date Revised 16.11.2017
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Defective Fas-mediated apoptosis in mice, caused by the gld mutation in the fas ligand gene, results in the development of lupus-like autoantibodies and severe lymphoproliferation. We previously demonstrated ectopic expression of the costimulatory molecule B7-1 (CD80) on T lymphocytes in B6/gld mice. This report extends these observations by demonstrating similar results in B6/lpr mice, which possess a mutation in the gene encoding Fas. Additionally, we demonstrate that this phenomenon is age-dependent and occurs on multiple subsets of B6/gld T lymphocytes. B7-1 upregulation is observed on T cells from both conventionally housed and specific-pathogen-free B6/gld mice, suggesting that this is not a consequence of infection by pathogen. T cells from lpr and gld mice show increased binding of CTLA4-Ig fusion protein, suggesting that the upregulated B7-1 is functional. CD28, a receptor for B7-1 which activates T cells, is upregulated in B6/lpr and B6/gld mice, while CTLA4, a negative regulator of T cells which binds B7-1, is not. Our results suggest that ectopic expression of B7-1 on T cells of lpr and gld mice may be playing a role in exacerbation of lymphoproliferation and/or autoimmunity
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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7 |
|a Antigens, Differentiation
|2 NLM
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| 650 |
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7 |
|a B7-1 Antigen
|2 NLM
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| 650 |
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7 |
|a CD28 Antigens
|2 NLM
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| 650 |
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7 |
|a CTLA-4 Antigen
|2 NLM
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| 650 |
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7 |
|a Ctla4 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Fas Ligand Protein
|2 NLM
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| 650 |
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7 |
|a Fasl protein, mouse
|2 NLM
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| 650 |
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7 |
|a Immunoconjugates
|2 NLM
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Abatacept
|2 NLM
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| 650 |
|
7 |
|a 7D0YB67S97
|2 NLM
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| 700 |
1 |
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|a Cohen, P L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 91(1999), 3 vom: 01. Juni, Seite 302-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:91
|g year:1999
|g number:3
|g day:01
|g month:06
|g pages:302-9
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 91
|j 1999
|e 3
|b 01
|c 06
|h 302-9
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