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01000naa a22002652 4500 |
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NLM100092896 |
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DE-627 |
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20231222115429.0 |
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231222s1999 xx ||||| 00| ||eng c |
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|a pubmed24n0334.xml
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|a (DE-627)NLM100092896
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|a (NLM)10075858
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Hiura, T S
|e verfasserin
|4 aut
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| 245 |
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|a Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade
|b implications for exacerbation of allergic inflammation by environmental pollutants
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| 264 |
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|c 1999
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 13.04.1999
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|a Date Revised 03.12.2021
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|a published: Print
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|a CommentIn: Clin Immunol. 1999 Mar;90(3):285-6. - PMID 10075857
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 1999 Academic Press.
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|a Macrophages are targeted by environmental pollutants and play a role in allergic inflammation. We explored the molecular basis for induction of RANTES (regulated upon activation, normal T-cells expressed and secreted) mRNA by lipopolysaccharide (LPS) and the redox-active quinone, tert-butylhydroxyquinone (tBHQ). We demonstrate that transcriptional activation of the human RANTES promoter by LPS is dependent on specific AP-1 and NF-kappaB response elements, which are regulated by c-Jun N-terminal kinase (JNK) and NF-kappaB kinase cascades, respectively. The transcriptional activation of the TRE3/4 site is mediated through the transcriptional activation of c-Jun by JNK. A c-Jun mutant which lacks a transcriptional activation domain interfered in the activation of the RANTES promoter. Similarly, kinase-inactive NF-kappaB inducing kinase interfered in the activation of the RANTES promoter. While activation of the RANTES promoter could also be blocked by the downstream kinase-inactive IkappaB kinases, only IKKalpha appears to be LPS-inducible. tBHQ also exerted subtle effects on the human RANTES promoter and induced mRNA expression in parallel with generating NF-kappaB shift complexes
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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|a Air Pollutants
|2 NLM
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| 650 |
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|a Chemokine CCL5
|2 NLM
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| 650 |
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|a Hydroquinones
|2 NLM
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| 650 |
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|a Lipopolysaccharides
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 650 |
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|a Transcription Factor AP-1
|2 NLM
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| 650 |
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|a 2-tert-butylhydroquinone
|2 NLM
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| 650 |
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|a C12674942B
|2 NLM
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| 650 |
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|a Protein Serine-Threonine Kinases
|2 NLM
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| 650 |
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|a EC 2.7.11.1
|2 NLM
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| 650 |
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|a CHUK protein, human
|2 NLM
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| 650 |
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|a EC 2.7.11.10
|2 NLM
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| 650 |
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|a I-kappa B Kinase
|2 NLM
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| 650 |
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|a EC 2.7.11.10
|2 NLM
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| 650 |
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|a IKBKB protein, human
|2 NLM
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| 650 |
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|a EC 2.7.11.10
|2 NLM
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| 650 |
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|a IKBKE protein, human
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.10
|2 NLM
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| 650 |
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|a Calcium-Calmodulin-Dependent Protein Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.17
|2 NLM
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| 650 |
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|a JNK Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.24
|2 NLM
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| 650 |
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7 |
|a Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.24
|2 NLM
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| 700 |
1 |
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|a Kempiak, S J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nel, A E
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 90(1999), 3 vom: 01. März, Seite 287-301
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:90
|g year:1999
|g number:3
|g day:01
|g month:03
|g pages:287-301
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 90
|j 1999
|e 3
|b 01
|c 03
|h 287-301
|