Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors

Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors

A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University stagi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 42(1996), 9 vom: 01. Sept., Seite 699-704
1. Verfasser: Nonomura, K (VerfasserIn)
Weitere Verfasser: Shinohara, N, Shinno, Y, Seki, T, Koyanagi, T, Nagamori, S, Fujieda, J, Togashi, M, Ohashi, N, Abe, N, Toyota, K, Maru, A, Gotoh, T, Sakakibara, N, Sakashita, S, Kosugi, M, Adachi, Y
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1996
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Clinical Trial English Abstract Journal Article Multicenter Study Randomized Controlled Trial Recombinant Proteins Bleomycin 11056-06-7 Granulocyte Colony-Stimulating Factor 143011-72-7 mehr... Etoposide 6PLQ3CP4P3 Cisplatin Q20Q21Q62J
LEADER 01000caa a22002652 4500
001 NLM088857069
003 DE-627
005 20250130212045.0
007 tu
008 231222s1996 xx ||||| 00| ||jpn c
028 5 2 |a pubmed25n0297.xml 
035 |a (DE-627)NLM088857069 
035 |a (NLM)8918674 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a jpn 
100 1 |a Nonomura, K  |e verfasserin  |4 aut 
245 1 0 |a Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors 
264 1 |c 1996 
336 |a Text  |b txt  |2 rdacontent 
337 |a ohne Hilfsmittel zu benutzen  |b n  |2 rdamedia 
338 |a Band  |b nc  |2 rdacarrier 
500 |a Date Completed 21.01.1997 
500 |a Date Revised 21.11.2013 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University staging system. Combination chemotherapy using bleomycin, etoposide and cisplatinum (BEP) was performed as the initial treatment on the eligible patients. rG-CSF was administered by two different methods; 1) routine administration on the 6th day after BEP chemotherapy (group A), and 2) the same method, but after granulocytopenia of 1,500/mm3 had developed (group B). The administration of rG-CSF in group A significantly reduced the severity of leucocytopenia and also the incidence of stomatitis compared with group B. Although rG-CSF produced no significant side effects, the thrombocytopenia was prominent in the group A patients (not significant). BEP chemotherapy itself is an easily-tolerable and well established method for treating young adult patients. The method used in group B seems to be suitable in situations where thrombocytopenia and cost effectiveness 
650 4 |a Clinical Trial 
650 4 |a English Abstract 
650 4 |a Journal Article 
650 4 |a Multicenter Study 
650 4 |a Randomized Controlled Trial 
650 7 |a Recombinant Proteins  |2 NLM 
650 7 |a Bleomycin  |2 NLM 
650 7 |a 11056-06-7  |2 NLM 
650 7 |a Granulocyte Colony-Stimulating Factor  |2 NLM 
650 7 |a 143011-72-7  |2 NLM 
650 7 |a Etoposide  |2 NLM 
650 7 |a 6PLQ3CP4P3  |2 NLM 
650 7 |a Cisplatin  |2 NLM 
650 7 |a Q20Q21Q62J  |2 NLM 
700 1 |a Shinohara, N  |e verfasserin  |4 aut 
700 1 |a Shinno, Y  |e verfasserin  |4 aut 
700 1 |a Seki, T  |e verfasserin  |4 aut 
700 1 |a Koyanagi, T  |e verfasserin  |4 aut 
700 1 |a Nagamori, S  |e verfasserin  |4 aut 
700 1 |a Fujieda, J  |e verfasserin  |4 aut 
700 1 |a Togashi, M  |e verfasserin  |4 aut 
700 1 |a Ohashi, N  |e verfasserin  |4 aut 
700 1 |a Abe, N  |e verfasserin  |4 aut 
700 1 |a Toyota, K  |e verfasserin  |4 aut 
700 1 |a Maru, A  |e verfasserin  |4 aut 
700 1 |a Gotoh, T  |e verfasserin  |4 aut 
700 1 |a Sakakibara, N  |e verfasserin  |4 aut 
700 1 |a Sakashita, S  |e verfasserin  |4 aut 
700 1 |a Kosugi, M  |e verfasserin  |4 aut 
700 1 |a Adachi, Y  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Hinyokika kiyo. Acta urologica Japonica  |d 1962  |g 42(1996), 9 vom: 01. Sept., Seite 699-704  |w (DE-627)NLM012631779  |x 0018-1994  |7 nnns 
773 1 8 |g volume:42  |g year:1996  |g number:9  |g day:01  |g month:09  |g pages:699-704 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_20 
912 |a GBV_ILN_22 
912 |a GBV_ILN_40 
912 |a GBV_ILN_60 
912 |a GBV_ILN_72 
912 |a GBV_ILN_120 
912 |a GBV_ILN_350 
912 |a GBV_ILN_2001 
912 |a GBV_ILN_2003 
912 |a GBV_ILN_2005 
912 |a GBV_ILN_2006 
912 |a GBV_ILN_2008 
912 |a GBV_ILN_2010 
912 |a GBV_ILN_2012 
912 |a GBV_ILN_2018 
951 |a AR 
952 |d 42  |j 1996  |e 9  |b 01  |c 09  |h 699-704