Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors

A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University stagi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:	Hinyokika kiyo. Acta urologica Japonica. - 1962. - 42(1996), 9 vom: 01. Sept., Seite 699-704
1. Verfasser:	Nonomura, K (VerfasserIn)
Weitere Verfasser:	Shinohara, N, Shinno, Y, Seki, T, Koyanagi, T, Nagamori, S, Fujieda, J, Togashi, M, Ohashi, N, Abe, N, Toyota, K, Maru, A, Gotoh, T, Sakakibara, N, Sakashita, S, Kosugi, M, Adachi, Y
Format:	Aufsatz
Sprache:	Japanese
Veröffentlicht:	1996
Zugriff auf das übergeordnete Werk:	Hinyokika kiyo. Acta urologica Japonica
Schlagworte:	Clinical Trial English Abstract Journal Article Multicenter Study Randomized Controlled Trial Recombinant Proteins Bleomycin 11056-06-7 Granulocyte Colony-Stimulating Factor 143011-72-7 mehr... Etoposide 6PLQ3CP4P3 Cisplatin Q20Q21Q62J

Beschreibung
Zusammenfassung:	A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University staging system. Combination chemotherapy using bleomycin, etoposide and cisplatinum (BEP) was performed as the initial treatment on the eligible patients. rG-CSF was administered by two different methods; 1) routine administration on the 6th day after BEP chemotherapy (group A), and 2) the same method, but after granulocytopenia of 1,500/mm3 had developed (group B). The administration of rG-CSF in group A significantly reduced the severity of leucocytopenia and also the incidence of stomatitis compared with group B. Although rG-CSF produced no significant side effects, the thrombocytopenia was prominent in the group A patients (not significant). BEP chemotherapy itself is an easily-tolerable and well established method for treating young adult patients. The method used in group B seems to be suitable in situations where thrombocytopenia and cost effectiveness
Beschreibung:	Date Completed 21.01.1997 Date Revised 21.11.2013 published: Print Citation Status MEDLINE
ISSN:	0018-1994