Trophoblast antigens in human seminal plasma

Secondary recurrent spontaneous (2 degrees) aborters manifest persistent IgG, which show differential cytotoxicity patterns with lymphocytes from many donors. These are non-HLA-directed antibodies, which react allotypically with both trophoblast and lymphocytes. The antigens they recognize are desig...

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Bibliographische Detailangaben
Veröffentlicht in:American journal of reproductive immunology and microbiology : AJRIM. - 1985. - 17(1988), 3 vom: 23. Juli, Seite 91-5
1. Verfasser: Kajino, T (VerfasserIn)
Weitere Verfasser: Torry, D S, McIntyre, J A, Faulk, W P
Format: Aufsatz
Sprache:English
Veröffentlicht: 1988
Zugriff auf das übergeordnete Werk:American journal of reproductive immunology and microbiology : AJRIM
Schlagworte:Journal Article Autoantigens Isoantibodies Isoantigens trophoblast-lymphocyte cross-reactive antigens
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245 1 0 |a Trophoblast antigens in human seminal plasma 
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520 |a Secondary recurrent spontaneous (2 degrees) aborters manifest persistent IgG, which show differential cytotoxicity patterns with lymphocytes from many donors. These are non-HLA-directed antibodies, which react allotypically with both trophoblast and lymphocytes. The antigens they recognize are designated trophoblast-lymphocyte crossreactive (TLX) antigens. Xenogeneic anti-TLX sera were studied with the use of enzyme-linked-immunosorbent (ELISA) and immunochemical assays to determine the TLX status of seminal plasma. The results showed 1) allotypic TLX antigens are present in seminal plasma; 2) seminal plasma TLX antigens may be membrane associated; 3) by immunoblotting, the molecular weights of antigens reactive with TLX antisera are 15, 22, 28, 33 kD and a smear between 180 and 340 kd; 4) by isoelectric focusing, TLX antigens show pI 4.0, 5.35, 5.9, 6.5, 6.8, and 7.2. Allotypic seminal plasma TLX antigens may provide the antigenic stimuli for persistent maternal humoral immunity 
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700 1 |a McIntyre, J A  |e verfasserin  |4 aut 
700 1 |a Faulk, W P  |e verfasserin  |4 aut 
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