Trophoblast antigens in human seminal plasma
Secondary recurrent spontaneous (2 degrees) aborters manifest persistent IgG, which show differential cytotoxicity patterns with lymphocytes from many donors. These are non-HLA-directed antibodies, which react allotypically with both trophoblast and lymphocytes. The antigens they recognize are desig...
| Veröffentlicht in: | American journal of reproductive immunology and microbiology : AJRIM. - 1985. - 17(1988), 3 vom: 23. Juli, Seite 91-5 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
1988
|
| Zugriff auf das übergeordnete Werk: | American journal of reproductive immunology and microbiology : AJRIM |
| Schlagworte: | Journal Article Autoantigens Isoantibodies Isoantigens trophoblast-lymphocyte cross-reactive antigens |
| Zusammenfassung: | Secondary recurrent spontaneous (2 degrees) aborters manifest persistent IgG, which show differential cytotoxicity patterns with lymphocytes from many donors. These are non-HLA-directed antibodies, which react allotypically with both trophoblast and lymphocytes. The antigens they recognize are designated trophoblast-lymphocyte crossreactive (TLX) antigens. Xenogeneic anti-TLX sera were studied with the use of enzyme-linked-immunosorbent (ELISA) and immunochemical assays to determine the TLX status of seminal plasma. The results showed 1) allotypic TLX antigens are present in seminal plasma; 2) seminal plasma TLX antigens may be membrane associated; 3) by immunoblotting, the molecular weights of antigens reactive with TLX antisera are 15, 22, 28, 33 kD and a smear between 180 and 340 kd; 4) by isoelectric focusing, TLX antigens show pI 4.0, 5.35, 5.9, 6.5, 6.8, and 7.2. Allotypic seminal plasma TLX antigens may provide the antigenic stimuli for persistent maternal humoral immunity |
|---|---|
| Beschreibung: | Date Completed 17.01.1989 Date Revised 29.10.2019 published: Print Citation Status MEDLINE |
| ISSN: | 8755-8920 |