Plasma methotrexate concentrations in urothelial cancer chemotherapy
The plasma methotrexate (MTX) concentration was measured during 50 courses of chemotherapy on 26 urothelial cancer patients. A dose of 300 mg/body MTX was infused within 2 hours and plasma concentrations were measured at the scheduled times. Plasma level at the end of infusion was (2.3 +/- 0.8) x 10...
| Publié dans: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 36(1990), 9 vom: 14. Sept., Seite 991-6 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article |
| Langue: | Japanese |
| Publié: |
1990
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| Accès à la collection: | Hinyokika kiyo. Acta urologica Japonica |
| Sujets: | English Abstract Journal Article Etoposide 6PLQ3CP4P3 Cisplatin Q20Q21Q62J Methotrexate YL5FZ2Y5U1 |
| Résumé: | The plasma methotrexate (MTX) concentration was measured during 50 courses of chemotherapy on 26 urothelial cancer patients. A dose of 300 mg/body MTX was infused within 2 hours and plasma concentrations were measured at the scheduled times. Plasma level at the end of infusion was (2.3 +/- 0.8) x 10(-5) M/L, (2.9 +/- 1.9) x 10(-5) M/L at the 6th-hour, and (1.9 +/- 1.8) x 10(-7) M/L at the 24th-hour after the infusion. The plasma MTX concentration values were inversely correlated with creatinin clearance. In 6 cases of Kock pouch bladder, clean intermittent self catheterization of urine caused no meaningful increase of MTX |
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| Description: | Date Completed 21.12.1990 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |