Prophylactic effect of UFT on the recurrence of bladder cancer
To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were giv...
| Publié dans: | Hinyokika kiyo. Acta urologica Japonica. - 1962. - 36(1990), 4 vom: 04. Apr., Seite 487-94 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , , , |
| Format: | Article |
| Langue: | Japanese |
| Publié: |
1990
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| Accès à la collection: | Hinyokika kiyo. Acta urologica Japonica |
| Sujets: | Clinical Trial English Abstract Journal Article Multicenter Study Randomized Controlled Trial Tegafur 1548R74NSZ Uracil 56HH86ZVCT |
| Résumé: | To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were given UFT and 55 were followed up without any medication. The non-recurrence rate in the group treated with UFT was 62.8% after 1 year and 36.3% after 2 years of follow up, and that of the control group was 45.7% and 39.5%, respectively. The rate of non-recurrence in the UFT group was significantly higher (p less than 0.05) than that of the control group during the period of follow up for 2 years. The incidence of side effects was 6.8% in UFT patients. These results indicate the clinical usefulness of prophylactic administration of UFT for bladder cancer patients |
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| Description: | Date Completed 05.09.1990 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
| ISSN: | 0018-1994 |