Prophylactic effect of UFT on the recurrence of bladder cancer

To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were giv...

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Détails bibliographiques
Publié dans:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 36(1990), 4 vom: 04. Apr., Seite 487-94
Auteur principal: Naito, K (Auteur)
Autres auteurs: Hisazumi, H, Saka, A, Nakamura, T, Kanda, S, Mikawa, I, Ejiri, S, Miyagi, T, Katsumi, T, Kitagawa, K
Format: Article
Langue:Japanese
Publié: 1990
Accès à la collection:Hinyokika kiyo. Acta urologica Japonica
Sujets:Clinical Trial English Abstract Journal Article Multicenter Study Randomized Controlled Trial Tegafur 1548R74NSZ Uracil 56HH86ZVCT
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520 |a To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were given UFT and 55 were followed up without any medication. The non-recurrence rate in the group treated with UFT was 62.8% after 1 year and 36.3% after 2 years of follow up, and that of the control group was 45.7% and 39.5%, respectively. The rate of non-recurrence in the UFT group was significantly higher (p less than 0.05) than that of the control group during the period of follow up for 2 years. The incidence of side effects was 6.8% in UFT patients. These results indicate the clinical usefulness of prophylactic administration of UFT for bladder cancer patients 
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