Clinical evaluation of urinary glycyl-prolyl dipeptidyl aminopeptidase in patients with urological disease

Urinary glycyl-prolyl dipeptidyl aminopeptidase (GP-DAP) activity was measured in 18 healthy adults and 252 patients with urological diseases. The GP-DAP activity was significantly higher in patients with prostatic cancer, bladder cancer or renal cancer and also in patients with acute prostatitis or...

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Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 36(1990), 12 vom: 29. Dez., Seite 1391-6
1. Verfasser: Kitamura, Y (VerfasserIn)
Weitere Verfasser: Watanabe, M, Komatsubara, S, Sakata, Y
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 1990
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Journal Article Acetylglucosaminidase EC 3.2.1.52 Aminopeptidases EC 3.4.11.- CD13 Antigens EC 3.4.11.2 Dipeptidyl-Peptidases and Tripeptidyl-Peptidases EC 3.4.14.- Dipeptidyl Peptidase 4 EC 3.4.14.5
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520 |a Urinary glycyl-prolyl dipeptidyl aminopeptidase (GP-DAP) activity was measured in 18 healthy adults and 252 patients with urological diseases. The GP-DAP activity was significantly higher in patients with prostatic cancer, bladder cancer or renal cancer and also in patients with acute prostatitis or pyelonephritis than in healthy adults. GP-DAP activity was also studied during anticancerous chemotherapy and proved to be a sensitive parameter for renal damage as are urinary N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase, beta 2-microglobulin, alpha 1-microglobulin, and albumin. The analysis of tissue activities suggested that GP-DAP was located not only in the renal parenchyma but also in the prostate and seminal vesicles 
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650 7 |a EC 3.4.11.-  |2 NLM 
650 7 |a CD13 Antigens  |2 NLM 
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700 1 |a Komatsubara, S  |e verfasserin  |4 aut 
700 1 |a Sakata, Y  |e verfasserin  |4 aut 
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