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01000naa a22002652 4500 |
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NLM015113019 |
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DE-627 |
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20231221062455.0 |
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tu |
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231221s1992 xx ||||| 00| ||jpn c |
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5 |
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|a pubmed24n0051.xml
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|a (DE-627)NLM015113019
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|a (NLM)1529813
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a jpn
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| 100 |
1 |
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|a Kamoto, T
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Neoadjuvant chemotherapy (M-VAC) for locally invasive bladder cancer
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| 264 |
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1 |
|c 1992
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.10.1992
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| 500 |
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|a Date Revised 21.11.2013
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Eight patients with locally invasive bladder cancer (stages T2-T4, N0, M0; 7 men and 1 woman; mean age, 72.0 years; age range, 56 to 80 years) were treated with 2 cycles of neoadjuvant chemotherapy consisting of methotrexate, vinblastine, adriamycin and cisplatin (M-VAC). Seven of them underwent radical cystectomy after chemotherapy, while the bladder was preserved in one patient. Seven patients were free of disease during a mean follow-up period of 26.2 months (range 20-30 months). However, one patient whose pathological stage was pT2, N1 died with disease 27 months after radical cystectomy. The patient whose bladder had been preserved showed no recurrence after a follow-up period of 27 months. Pathological examination of the resected specimen after chemotherapy revealed no tumor tissue in three patients; one with negative cytology and two with positive cytology. Downstages were observed in two patients. Results showed that the toxicity of neoadjuvant M-VAC therapy is acceptable and that M-VAC therapy is effective against locally invasive transitional cell carcinoma of the bladder. The problem remains of how to assess the clinical stage more accurately before chemotherapy and radical cystectomy
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Vinblastine
|2 NLM
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| 650 |
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7 |
|a 5V9KLZ54CY
|2 NLM
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| 650 |
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7 |
|a Doxorubicin
|2 NLM
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| 650 |
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7 |
|a 80168379AG
|2 NLM
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| 650 |
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7 |
|a Cisplatin
|2 NLM
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| 650 |
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7 |
|a Q20Q21Q62J
|2 NLM
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| 650 |
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7 |
|a Methotrexate
|2 NLM
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| 650 |
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7 |
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|2 NLM
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| 700 |
1 |
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|a Kawakita, M
|e verfasserin
|4 aut
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1 |
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|a Okabe, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsumoto, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsuda, T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yoshida, O
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 38(1992), 4 vom: 27. Apr., Seite 405-11
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:1992
|g number:4
|g day:27
|g month:04
|g pages:405-11
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|d 38
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