Geographic Clustering of Polygenic Scores at Different Stages of the Life Course

We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores...

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Veröffentlicht in:RSF: The Russell Sage Foundation Journal of the Social Sciences. - Russell Sage Foundation. - 4(2018), 4, Seite 137-149
Format: Online-Aufsatz
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:RSF: The Russell Sage Foundation Journal of the Social Sciences
Schlagworte:polygenic scores genetics geography Biological sciences Education Mathematics Physical sciences
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520 |a We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individualás educational attainment net of that personás polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research. 
540 |a © 2018 Russell Sage Foundation 
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