Geographic Clustering of Polygenic Scores at Different Stages of the Life Course
We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores...
Veröffentlicht in: | RSF: The Russell Sage Foundation Journal of the Social Sciences. - Russell Sage Foundation. - 4(2018), 4, Seite 137-149 |
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Format: | Online-Aufsatz |
Veröffentlicht: |
2018
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Zugriff auf das übergeordnete Werk: | RSF: The Russell Sage Foundation Journal of the Social Sciences |
Schlagworte: | polygenic scores genetics geography Biological sciences Education Mathematics Physical sciences |
Zusammenfassung: | We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individualás educational attainment net of that personás polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research. |
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ISSN: | 23778261 |