Absolute Rate Theories of Epigenetic Stability

Absolute Rate Theories of Epigenetic Stability

Spontaneous switching events in most characterized genetic switches are rare, resulting in extremely stable epigenetic properties. We show how simple arguments lead to theories of the rate of such events much like the absolute rate theory of chemical reactions corrected by a transmission factor. Bot...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 102(2005), 52, Seite 18926-18931
Weitere Verfasser: Onuchic, José N., Wolynes, Peter G.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Proceedings of the National Academy of Sciences of the United States of America
Schlagworte:Rate Theory Stochastic Gene Expression Gene Switches Physical sciences Biological sciences Mathematics
LEADER 01000caa a22002652 4500
001 JST07017766X
003 DE-627
005 20240622204237.0
007 cr uuu---uuuuu
008 150325s2005 xx |||||o 00| ||eng c
035 |a (DE-627)JST07017766X 
035 |a (JST)4152542 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
245 1 0 |a Absolute Rate Theories of Epigenetic Stability 
264 1 |c 2005 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
520 |a Spontaneous switching events in most characterized genetic switches are rare, resulting in extremely stable epigenetic properties. We show how simple arguments lead to theories of the rate of such events much like the absolute rate theory of chemical reactions corrected by a transmission factor. Both the probability of the rare cellular states that allow epigenetic escape and the transmission factor depend on the rates of DNA binding and unbinding events and on the rates of protein synthesis and degradation. Different mechanisms of escape from the stable attractors occur in the nonadiabatic, weakly adiabatic, and strictly adiabatic regimes, characterized by the relative values of those input rates. 
540 |a Copyright 1993-2005 National Academy of Sciences of the United States of America 
650 4 |a Rate Theory 
650 4 |a Stochastic Gene Expression 
650 4 |a Gene Switches 
650 4 |a Physical sciences  |x Chemistry  |x Chemical compounds  |x Chemicals  |x Acids  |x Nucleic acids  |x DNA 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Genomics  |x Epigenetics 
650 4 |a Physical sciences  |x Physics  |x Microphysics  |x Particle physics  |x Particle motion  |x Mean free path 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Molecular genetics 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Molecular genetics  |x Genes 
650 4 |a Physical sciences  |x Chemistry  |x Chemical compounds  |x Chemicals  |x Polymers  |x Biopolymers  |x Proteins  |x DNA binding proteins  |x Transcription factors 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Population genetics  |x Genetic equilibrium 
650 4 |a Mathematics  |x Mathematical procedures  |x Approximation 
650 4 |a Biological sciences  |x Biology  |x Genetics  |x Molecular genetics  |x Genetic translation  |x Protein synthesis 
650 4 |a Mathematics  |x Applied mathematics  |x Statistics  |x Applied statistics  |x Descriptive statistics  |x Statistical distributions  |x Distribution functions  |x Probability distributions  |x Biological Sciences 
655 4 |a research-article 
700 1 |a Onuchic, José N.  |e verfasserin  |4 aut 
700 1 |a Wolynes, Peter G.  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Proceedings of the National Academy of Sciences of the United States of America  |d National Academy of Sciences of the United States of America  |g 102(2005), 52, Seite 18926-18931  |w (DE-627)254235379  |w (DE-600)1461794-8  |x 10916490  |7 nnns 
773 1 8 |g volume:102  |g year:2005  |g number:52  |g pages:18926-18931 
856 4 0 |u https://www.jstor.org/stable/4152542  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_JST 
912 |a GBV_ILN_11 
912 |a GBV_ILN_20 
912 |a GBV_ILN_22 
912 |a GBV_ILN_23 
912 |a GBV_ILN_24 
912 |a GBV_ILN_31 
912 |a GBV_ILN_39 
912 |a GBV_ILN_40 
912 |a GBV_ILN_60 
912 |a GBV_ILN_62 
912 |a GBV_ILN_63 
912 |a GBV_ILN_65 
912 |a GBV_ILN_69 
912 |a GBV_ILN_70 
912 |a GBV_ILN_73 
912 |a GBV_ILN_74 
912 |a GBV_ILN_90 
912 |a GBV_ILN_95 
912 |a GBV_ILN_100 
912 |a GBV_ILN_105 
912 |a GBV_ILN_110 
912 |a GBV_ILN_120 
912 |a GBV_ILN_151 
912 |a GBV_ILN_161 
912 |a GBV_ILN_168 
912 |a GBV_ILN_170 
912 |a GBV_ILN_171 
912 |a GBV_ILN_213 
912 |a GBV_ILN_230 
912 |a GBV_ILN_252 
912 |a GBV_ILN_285 
912 |a GBV_ILN_293 
912 |a GBV_ILN_370 
912 |a GBV_ILN_374 
912 |a GBV_ILN_381 
912 |a GBV_ILN_602 
912 |a GBV_ILN_702 
912 |a GBV_ILN_2001 
912 |a GBV_ILN_2003 
912 |a GBV_ILN_2005 
912 |a GBV_ILN_2006 
912 |a GBV_ILN_2009 
912 |a GBV_ILN_2010 
912 |a GBV_ILN_2011 
912 |a GBV_ILN_2014 
912 |a GBV_ILN_2015 
912 |a GBV_ILN_2018 
912 |a GBV_ILN_2020 
912 |a GBV_ILN_2021 
912 |a GBV_ILN_2026 
912 |a GBV_ILN_2027 
912 |a GBV_ILN_2044 
912 |a GBV_ILN_2050 
912 |a GBV_ILN_2057 
912 |a GBV_ILN_2061 
912 |a GBV_ILN_2088 
912 |a GBV_ILN_2107 
912 |a GBV_ILN_2110 
912 |a GBV_ILN_2190 
912 |a GBV_ILN_2360 
912 |a GBV_ILN_2943 
912 |a GBV_ILN_2946 
912 |a GBV_ILN_2949 
912 |a GBV_ILN_2951 
912 |a GBV_ILN_4012 
912 |a GBV_ILN_4035 
912 |a GBV_ILN_4037 
912 |a GBV_ILN_4046 
912 |a GBV_ILN_4112 
912 |a GBV_ILN_4125 
912 |a GBV_ILN_4126 
912 |a GBV_ILN_4242 
912 |a GBV_ILN_4249 
912 |a GBV_ILN_4251 
912 |a GBV_ILN_4305 
912 |a GBV_ILN_4306 
912 |a GBV_ILN_4307 
912 |a GBV_ILN_4313 
912 |a GBV_ILN_4322 
912 |a GBV_ILN_4323 
912 |a GBV_ILN_4324 
912 |a GBV_ILN_4325 
912 |a GBV_ILN_4335 
912 |a GBV_ILN_4338 
912 |a GBV_ILN_4346 
912 |a GBV_ILN_4367 
912 |a GBV_ILN_4393 
912 |a GBV_ILN_4700 
951 |a AR 
952 |d 102  |j 2005  |e 52  |h 18926-18931