Absolute Rate Theories of Epigenetic Stability

Spontaneous switching events in most characterized genetic switches are rare, resulting in extremely stable epigenetic properties. We show how simple arguments lead to theories of the rate of such events much like the absolute rate theory of chemical reactions corrected by a transmission factor. Bot...

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 102(2005), 52, Seite 18926-18931
Weitere Verfasser: Onuchic, José N., Wolynes, Peter G.
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Proceedings of the National Academy of Sciences of the United States of America
Schlagworte:Rate Theory Stochastic Gene Expression Gene Switches Physical sciences Biological sciences Mathematics