DNA and RNA Virus Species are Inhibited by Xanthates, a Class of Antiviral Compounds with Unique Properties

Various DNA and RNA virus species are inhibited by xanthate compounds at concentrations that leave the mitotic activity of uninfected cells unimpaired. The concentration of tricyclodecan-9-yl-xanthogenate that reduces the yield of herpes simplex virus types 1 and 2 by 50% is between 4.5 and 33 μ M....

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 81(1984), 11, Seite 3263-3267
1. Verfasser:	Sauer, Gerhard (VerfasserIn)
Weitere Verfasser:	Amtmann, Eberhard, Melber, Karl, Knapp, Anita, Müller, Karin, Hummel, Klaus, Scherm, Arthur
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	1984
Zugriff auf das übergeordnete Werk:	Proceedings of the National Academy of Sciences of the United States of America
Schlagworte:	Applied Biology Inhibitors Viral Replication Transformation Reversion Physical sciences Health sciences Biological sciences


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100	1		\|a Sauer, Gerhard \|e verfasserin \|4 aut
245	1	0	\|a DNA and RNA Virus Species are Inhibited by Xanthates, a Class of Antiviral Compounds with Unique Properties
264		1	\|c 1984
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520			\|a Various DNA and RNA virus species are inhibited by xanthate compounds at concentrations that leave the mitotic activity of uninfected cells unimpaired. The concentration of tricyclodecan-9-yl-xanthogenate that reduces the yield of herpes simplex virus types 1 and 2 by 50% is between 4.5 and 33 μ M. The replication of DNA viruses such as simian virus 40 can be blocked at the DNA and RNA level both early and late after infection. The xanthates are not incorporated into nucleic acids. Episomal bovine papilloma virus DNA replication and transcription are also inhibited in transformed cells. The treated cells revert to the normal phenotype by acquisition of contact inhibition and a flat morphology.
650		4	\|a Applied Biology
650		4	\|a Inhibitors
650		4	\|a Viral Replication
650		4	\|a Transformation
650		4	\|a Reversion
650		4	\|a Physical sciences \|x Chemistry \|x Chemical compounds \|x Chemicals \|x Acids \|x Nucleic acids \|x DNA
650		4	\|a Health sciences \|x Medical sciences \|x Pharmaceutics \|x Pharmaceutical preparations \|x Medications \|x Antiinfectives \|x Antivirals
650		4	\|a Biological sciences \|x Biology \|x Microbiology \|x Microorganisms \|x Viruses
650		4	\|a Health sciences \|x Medical conditions \|x Infections
650		4	\|a Biological sciences \|x Biology \|x Cytology \|x Cell biology \|x Cells \|x Cultured cells \|x Cell lines
650		4	\|a Biological sciences \|x Biology \|x Cytology \|x Cell biology \|x Cells \|x Kidney cells
650		4	\|a Biological sciences \|x Biology \|x Cytology \|x Cell biology \|x Cells \|x Cultured cells \|x Cell lines \|x Tumor cell line \|x HeLa cells
650		4	\|a Biological sciences \|x Biology \|x Microbiology \|x Microorganisms \|x Viruses \|x DNA viruses \|x Herpesviridae \|x Simplexvirus \|x Human herpesvirus 1
650		4	\|a Physical sciences \|x Chemistry \|x Chemical compounds \|x Chemicals \|x Acids \|x Nucleic acids \|x RNA
650		4	\|a Biological sciences \|x Biology \|x Cytology \|x Cell biology \|x Cell physiology \|x Cell growth
655		4	\|a research-article
700	1		\|a Amtmann, Eberhard \|e verfasserin \|4 aut
700	1		\|a Melber, Karl \|e verfasserin \|4 aut
700	1		\|a Knapp, Anita \|e verfasserin \|4 aut
700	1		\|a Müller, Karin \|e verfasserin \|4 aut
700	1		\|a Hummel, Klaus \|e verfasserin \|4 aut
700	1		\|a Scherm, Arthur \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Proceedings of the National Academy of Sciences of the United States of America \|d National Academy of Sciences of the United States of America \|g 81(1984), 11, Seite 3263-3267 \|w (DE-627)254235379 \|w (DE-600)1461794-8 \|x 10916490 \|7 nnns
773	1	8	\|g volume:81 \|g year:1984 \|g number:11 \|g pages:3263-3267
856	4	0	\|u https://www.jstor.org/stable/23814 \|3 Volltext
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912			\|a SYSFLAG_A
912			\|a GBV_JST
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_168
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_252
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_374
912			\|a GBV_ILN_381
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2018
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2360
912			\|a GBV_ILN_2943
912			\|a GBV_ILN_2946
912			\|a GBV_ILN_2949
912			\|a GBV_ILN_2951
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4346
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 81 \|j 1984 \|e 11 \|h 3263-3267