DNA and RNA Virus Species are Inhibited by Xanthates, a Class of Antiviral Compounds with Unique Properties

DNA and RNA Virus Species are Inhibited by Xanthates, a Class of Antiviral Compounds with Unique Properties

Various DNA and RNA virus species are inhibited by xanthate compounds at concentrations that leave the mitotic activity of uninfected cells unimpaired. The concentration of tricyclodecan-9-yl-xanthogenate that reduces the yield of herpes simplex virus types 1 and 2 by 50% is between 4.5 and 33 μ M....

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences of the United States of America. - National Academy of Sciences of the United States of America. - 81(1984), 11, Seite 3263-3267
1. Verfasser: Sauer, Gerhard (VerfasserIn)
Weitere Verfasser: Amtmann, Eberhard, Melber, Karl, Knapp, Anita, Müller, Karin, Hummel, Klaus, Scherm, Arthur
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 1984
Zugriff auf das übergeordnete Werk:Proceedings of the National Academy of Sciences of the United States of America
Schlagworte:Applied Biology Inhibitors Viral Replication Transformation Reversion Physical sciences Health sciences Biological sciences
Beschreibung
Zusammenfassung:Various DNA and RNA virus species are inhibited by xanthate compounds at concentrations that leave the mitotic activity of uninfected cells unimpaired. The concentration of tricyclodecan-9-yl-xanthogenate that reduces the yield of herpes simplex virus types 1 and 2 by 50% is between 4.5 and 33 μ M. The replication of DNA viruses such as simian virus 40 can be blocked at the DNA and RNA level both early and late after infection. The xanthates are not incorporated into nucleic acids. Episomal bovine papilloma virus DNA replication and transcription are also inhibited in transformed cells. The treated cells revert to the normal phenotype by acquisition of contact inhibition and a flat morphology.
ISSN:10916490