Journal Article Activated phosphoinositide 3-kinase δ syndrome Antibodies, Monoclonal, Humanized Case Reports Class I Phosphatidylinositol 3-Kinases Cytokines EC 2.7.1.137 I031V2H011 Immunodeficiency Immunosuppressive Agents Interleukin-6 Intracellular Signaling Peptides and Proteins JAK inhibitor Janus Kinase Inhibitors Juvenile arthritis LACC1 deficiency LACC1 protein, human Loss-of-function Lymphoproliferation PIK3CD PIK3CD protein, human Prednisone Research Support, Non-U.S. Gov't Sirolimus Tocilizumab VB0R961HZT W36ZG6FT64 tocilizumab