Case Reports Journal Article Research Support, Non-U.S. Gov't Immunodeficiency Whole exome sequencing Atypical presentation DNA (Cytosine-5-)-Methyltransferases DNA-Binding Proteins DNMT3B EC 2.1.1.37 Epstein-Bar virus infections Familial Mediterranean fever Gene therapy Guanine Nucleotide Exchange Factors Hematopoietic stem cell transplantation ICF syndrome Immune cell function Immune dysregulation Letter Primary immunodeficiency Primary immunodeficiency disease Pyrin RASGRP1 deficiency RASGRP1 protein, human Severe combined immunodeficiency T cell function WAS protein, human Wiskott-Aldrich Syndrome Protein Wiskott-Aldrich syndrome, F-actin polymerization