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01000naa a22002652 4500 |
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WLY020262329 |
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DE-627 |
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20241127092347.0 |
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cr uuu---uuuuu |
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241127s2024 xx |||||o 00| ||und c |
| 024 |
7 |
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|a 10.1111/pim.13074
|2 doi
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| 028 |
5 |
2 |
|a 2024-11-27_PIM_2024_46_11.zip.xml
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|a (DE-627)WLY020262329
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|a (WILEY)PIM13074
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|a DE-627
|b ger
|c DE-627
|e rda
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| 100 |
1 |
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|a Viana, Kelvinson Fernandes
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Safety and Immunogenicity of an FhSAMS Vaccine Against Fasciola hepatica in Dairy Cattle
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| 264 |
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1 |
|c 2024
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| 300 |
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|a 8
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a Computermedien
|b c
|2 rdamedia
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| 338 |
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|a Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a © 2024 John Wiley & Sons Ltd.
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| 520 |
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|a ABSTRACT Fasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and health point of view. The aim of this study was to evaluate a new vaccine formulation for dairy cattle, containing soluble Fasciola hepatica antigens associated with Montanide 763 AVG and saponin adjuvants (FhSAMS). The vaccine was tested with two protocols, a single dose and a booster dose 6 months after the first dose. The FhSAMS vaccine proved to be safe, with no side effects. Furthermore, it was able to generate a more robust humoral immune response when a six‐month booster dose was used, in addition to stimulating greater production of IFN‐ʏ, indicating a Th1 profile immune stimulus.
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| 700 |
1 |
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|a Sperandio, Natânia do Carmo
|4 aut
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| 700 |
1 |
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|a Neto, Felipe Berbari
|4 aut
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| 700 |
1 |
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|a Donatele, Dirlei Molinari
|4 aut
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| 700 |
1 |
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|a Souza, Adrieli Barboza
|4 aut
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| 700 |
1 |
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|a Santos, Angelo Gabriel Vidal
|4 aut
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| 700 |
1 |
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|a Rivas, Açucena Veleh
|4 aut
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| 700 |
1 |
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|a Barcellos, Ema Carolina de Almeida
|4 aut
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| 700 |
1 |
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|a Martins, Isabella Vilhena Freire
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Parasite Immunology
|g 46(2024), 11
|w (DE-627)WLY012322709
|x 13653024
|7 nnns
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| 773 |
1 |
8 |
|g volume:46
|g year:2024
|g number:11
|g extent:8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_WLY
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_20
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| 912 |
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|a GBV_ILN_21
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| 912 |
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|a GBV_ILN_22
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| 912 |
|
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_39
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| 912 |
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|a GBV_ILN_40
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| 912 |
|
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|a GBV_ILN_60
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| 912 |
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|a GBV_ILN_70
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| 912 |
|
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|a GBV_ILN_110
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| 912 |
|
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|a GBV_ILN_121
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| 912 |
|
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|a GBV_ILN_206
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| 912 |
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|a GBV_ILN_350
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| 912 |
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|a GBV_ILN_618
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| 912 |
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|a GBV_ILN_2001
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| 912 |
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|a GBV_ILN_2005
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| 912 |
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|a GBV_ILN_2008
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| 912 |
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|a GBV_ILN_2009
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| 912 |
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|a GBV_ILN_2018
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| 912 |
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|a GBV_ILN_2035
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| 912 |
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|a GBV_ILN_2105
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| 951 |
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|a AR
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| 952 |
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|d 46
|j 2024
|e 11
|g 8
|