Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate

Abstract Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques...

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Veröffentlicht in:Parasite Immunology. - 44(2022), 7
1. Verfasser: Corral, Marcelo A. (VerfasserIn)
Weitere Verfasser: Gonçalves, Ana Lucia R., Costa, Idessania N., Abdala, Edson, Pierrotti, Ligia C., Chieffi, Pedro Paulo, Costa‐Cruz, Julia Maria, Gryschek, Ronaldo Cesar B., Paula, Fabiana Martins
Format: Online-Aufsatz
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Parasite Immunology
Umfang:5
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520 |a Abstract Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques using specific IgG and immune complexes (IC) detection can help in the diagnosis of these patients. This study aimed to detect specific anti‐ Strongyloides IC and IgG antibodies in kidney transplant (KT) and liver transplant (LT) candidates. A total of 100 blood samples was collected from transplant candidates (50 blood samples each from KT and LT candidates). Serum was obtained and analysed using enzyme‐linked immunosorbent assay for IC and IgG detections. The IC levels showed frequencies of 18% and 2% in the KT and LT groups, respectively, whereas anti‐ Strongyloides IgG was detected in 34% and 12% of KT and LT candidates, respectively. The correlation between IC and IgG detection is poor in KT candidates, while in LT candidates, there is a significant positive correlation. The detection of IC can be an additional tool for the diagnosis of strongyloidiasis, especially when associated with the detection of specific IgG anti‐ Strongyloides antibodies. 
700 1 |a Gonçalves, Ana Lucia R.  |4 aut 
700 1 |a Costa, Idessania N.  |4 aut 
700 1 |a Abdala, Edson  |4 aut 
700 1 |a Pierrotti, Ligia C.  |4 aut 
700 1 |a Chieffi, Pedro Paulo  |4 aut 
700 1 |a Costa‐Cruz, Julia Maria  |4 aut 
700 1 |a Gryschek, Ronaldo Cesar B.  |4 aut 
700 1 |a Paula, Fabiana Martins  |4 aut 
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