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230220s2020 xx |||||o 00| ||und c |
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|a 10.1111/pim.12706
|2 doi
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|a PIM_PIM12706.xml
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|2 bkl
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| 100 |
1 |
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|a Henning, Alischa
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi
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| 264 |
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1 |
|c 2020
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|a 10
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| 336 |
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|a Text
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|a Computermedien
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|a Online-Ressource
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|a Copyright © 2020 John Wiley & Sons Ltd
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|a Abstract To provide useful information based on the macropathology, histopathology and immunohistochemical investigation in the spleens of dogs with Babesia rossi infection. Control spleens were collected from four healthy dogs euthanized for welfare reasons. Nine dogs that died naturally because of a mono‐infection with Babesia rossi were selected for the diseased group. One haematoxylin‐and‐eosin–stained section of splenic tissue from each of the infected and control dogs was examined under the light microscope. Immunohistochemical markers were applied to characterize different immunocyte populations. The application of analytic software enabled semi‐quantitative comparison of leucocyte subpopulations. Routine splenic histopathology revealed diffuse intermingling of white and red pulp from infected dogs with a clear loss of distinction between these zones. Immunohistochemistry revealed an increase in the proportion of tissue resident and bone marrow origin macrophages in the infected spleens. Apart from a few remnant lymphocytes within the peri‐arteriolar lymphatic sheaths and follicles, the majority of the immunocytes redistributed to the red pulp, supporting the observation of white and red pulp intermingling. The majority of our findings are in agreement with histomorphological descriptions of the spleen in a variety of noncanid mammalian hosts with lethal malaria or babesiosis.
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| 700 |
1 |
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|a Clift, Sarah Jane
|4 aut
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| 700 |
1 |
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|a Leisewitz, Andrew Lambert
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Parasite Immunology
|g 42(2020), 5
|w (DE-627)WLY012322709
|x 13653024
|7 nnns
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| 773 |
1 |
8 |
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k |
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