Bridging Research and Application : Zn-Based Alloys as Next-Generation Biodegradable Orthopedic Implants
© 2025 Wiley‐VCH GmbH.
| Veröffentlicht in: | Advanced materials (Deerfield Beach, Fla.). - 1998. - (2025) vom: 17. Okt., Seite e13733 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2025
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| Zugriff auf das übergeordnete Werk: | Advanced materials (Deerfield Beach, Fla.) |
| Schlagworte: | Journal Article Review biodegradable zinc engineering modification future perspectives orthopedic implants remaining challenges |
| Zusammenfassung: | © 2025 Wiley‐VCH GmbH. Orthopedic implants provide structural support, loading-bearing, or motion preservation to ensure surgical success. Zinc (Zn)-based alloys have emerged as promising candidates for next-generation orthopedic implants due to their suitable degradation rate, excellent mechanical properties, antibacterial activity, and complete degradability. However, the clinical application of Zn-based alloys is hindered by significant limitations, including mechanical instability, threshold-dependent bioactivity, an inadequate balance between antimicrobial and osteogenic effects, and variability in stress-induced degradation. This comprehensive review summarizes the feasibility of Zn-based alloys for orthopedic implants, focusing on the biocompatibility, biodegradation behavior, mechanical properties, and interactions with the resident cells. The engineering methods to modify properties of Zn-based materials are also discussed, and their translational applications are highlighted, while addressing the remaining challenges for future investigation. Collectively, advancing research in Zn-based alloys would pave the way for innovative orthopedic solutions that enhance patient outcomes |
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| Beschreibung: | Date Revised 17.10.2025 published: Print-Electronic Citation Status Publisher |
| ISSN: | 1521-4095 |
| DOI: | 10.1002/adma.202513733 |