Targeted Lipid Transfer Nanoshuttle via Lipid-Specific Transcytosis Induces Atherosclerotic Plaque Regression

Targeted Lipid Transfer Nanoshuttle via Lipid-Specific Transcytosis Induces Atherosclerotic Plaque Regression

© 2025 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 38(2026), 4 vom: 29. Jan., Seite e11606
1. Verfasser: Tang, Shuling (VerfasserIn)
Weitere Verfasser: Cui, Yihao, Xiao, Yun, Li, Wujiao, Zhou, Yuemin, Li, Chen, Ma, Boxuan, Li, Chengbin, Li, Benke, Fu, Guosheng, Tang, Ruikang, Wang, Xiaoyu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2026
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article atherosclerosis biomaterials foam cells nanoparticles transcytosis Gold 7440-57-5 beta-Cyclodextrins betadex mehr... JV039JZZ3A Apolipoproteins E Lipids
Beschreibung
Zusammenfassung:© 2025 Wiley‐VCH GmbH.
Lipid transfer proteins (LTPs) orchestrate inter-membrane lipid transport through hydrophobic cavities, but their therapeutic application is limited by the requirement to simultaneously maintain dual-membrane targeting and lipid-carrying structures. Inspired by LTPs, a therapeutic platform coupling β-cyclodextrin (β-CD) with gold nanoparticles as a lipid-capturing shuttle (LipShuttle) is proposed. The β-CD specifically targets lipid droplets to sequester stored lipids, while the gold nanoparticles drive transcytotic lipid efflux. This dual mechanism enhances lipid removal, boosts neutral lipid catabolism, and reverses lipid overload in foam cells. Then LipShuttle's therapeutic efficacy is validated in high-fat diet-fed ApoE-/- mice with established atherosclerotic plaques. By combining ultrasound-enhanced lipid efflux with cell targeting, LipShuttle promotes plaque regression and reduces vulnerability. Mechanistically, LipShuttle-mediated lipid depletion suppresses arachidonic acid metabolism, attenuating inflammation, and reprograms plaque macrophages toward a pro-efferocytic phenotype. This dual action promotes plaque regression, demonstrating a promising lipid transfer-based therapeutic strategy for diseases driven by dysregulated lipid accumulation
Beschreibung:Date Completed 16.01.2026
Date Revised 16.01.2026
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202511606