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20251004232316.0 |
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251004s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202511733
|2 doi
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|a pubmed25n1589.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Jiang, Yuping
|e verfasserin
|4 aut
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| 245 |
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|a NIR-Driven Nanomotors Integrating With Platelet-Thylakoid Hybrid Membranes for Synchronized Thrombolysis and Vascular Remodeling
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 04.10.2025
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2025 Wiley‐VCH GmbH.
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|a The pathological interplay of oxidative stress, inflammation, and thrombosis driven by endothelial injury creates a self-perpetuating cycle that undermines conventional thrombolytic therapies. Herein, near-infrared (NIR)-responsive nanomotors are constructed by integrating thylakoid and platelet membranes on strontium-doped mesoporous polydopamine nanoparticles (PSrPT NPs), which enables synchronized thrombus dissolution and vascular microenvironment restoration. Following intravenous administration, PSr@PT nanomotors exhibited preferential accumulation within thrombi and were internalized by injured endothelial cells. Meanwhile, thylakoid-embedded catalase catalyzed endogenous hydrogen peroxide to oxygen, which can not only suppress oxidative damage and neutralize to disrupt platelet-endothelium interactions, but also generate self-propulsive forces via gas propulsion, facilitating deep intrathrombus penetration of PSr@PT NPs. Proteomic analysis revealed that PSr@PT NPs inhibited thrombosis progression by downregulating platelet activation and modulating JAK-STAT/PI3K-Akt signaling pathways, thereby reducing inflammation and fostering angiogenesis. Local NIR irradiation induced mild photothermal conversion of PSr@PT NPs, which softened fibrin networks, enhanced intrathrombus infiltration, and accelerated localized thrombolysis. In both FeCl3-induced murine carotid thrombosis and arachidonic acid-induced zebrafish thrombosis models, the PSr@PT NPs effectively resolved occlusions and restored endothelial function. By coupling ROS-powered propulsion with adaptive microenvironment remodeling, this nanomotor transcends conventional 1D clot lysis, offering a dynamic strategy to prevent thrombosis recurrence and accelerate functional vascular recovery
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|a Journal Article
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|a platelet membrane
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| 650 |
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4 |
|a polydopamine nanoparticles
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| 650 |
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4 |
|a thrombosis
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| 650 |
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4 |
|a thylakoid
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| 650 |
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4 |
|a vascular repair
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| 700 |
1 |
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|a Li, Yufeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Kexuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Xiaomin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Weiqing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Chensong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Jianfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Zhilu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Chuanbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Lu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2025) vom: 04. Okt., Seite e11733
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
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|g year:2025
|g day:04
|g month:10
|g pages:e11733
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|u http://dx.doi.org/10.1002/adma.202511733
|3 Volltext
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