Copper-Driven Allosteric and Self-Encapsulating Polymers for Tumor-Specific Fluorescence Imaging and Dual-Enzymatic Cancer Therapy

Copper-Driven Allosteric and Self-Encapsulating Polymers for Tumor-Specific Fluorescence Imaging and Dual-Enzymatic Cancer Therapy

© 2025 Wiley‐VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2025) vom: 30. Sept., Seite e05829
Auteur principal: Peng, Chuan (Auteur)
Autres auteurs: Zhang, Gang, Zhu, Yuling, Yao, Yu, Luo, Yan, Han, Guangqing, Wang, Yiwei, Zheng, Yi, Zhou, Yeqiang, Liu, Yang, Fu, Weili, Xue, Jianxin, Tan, Hong, Ding, Mingming
Format: Article en ligne
Langue:English
Publié: 2025
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article conformation drug delivery fluorescence imaging metal coordination polypeptide
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520 |a Metal ion-mediated redox process and protein folding are fundamental to numerous physiological functions. However, the mechanisms underlying copper ion interactions with macromolecules remain insufficiently understood, and the therapeutic potential of polymer-copper complexes is largely underexplored. Here, a biomimetic metallopolymer is reported in which copper ion coordination induces a conformational transition from β-sheet to α-helix, accompanied by oxidative self-encapsulation and fluorescence quenching. By leveraging the tunable intrinsic fluorescence of the polymer, the first systematic elucidation of the coordination interaction mechanism between polythiols and copper ions is presented. This interaction enhances the structural stability, catalytic efficiency, membrane activity, and drug loading capacity. Furthermore, the polymer-copper complex demonstrates tumor-activated fluorescence and dual enzyme-mimetic activities, enabling precise tumor imaging and multimodal therapeutic efficacy both in vitro and in vivo. This work provides new insights into the interactions between macromolecules and metal ions and establishes a versatile and intelligent nanosystem for advanced disease diagnostics and therapeutics 
650 4 |a Journal Article 
650 4 |a conformation 
650 4 |a drug delivery 
650 4 |a fluorescence imaging 
650 4 |a metal coordination 
650 4 |a polypeptide 
700 1 |a Zhang, Gang  |e verfasserin  |4 aut 
700 1 |a Zhu, Yuling  |e verfasserin  |4 aut 
700 1 |a Yao, Yu  |e verfasserin  |4 aut 
700 1 |a Luo, Yan  |e verfasserin  |4 aut 
700 1 |a Han, Guangqing  |e verfasserin  |4 aut 
700 1 |a Wang, Yiwei  |e verfasserin  |4 aut 
700 1 |a Zheng, Yi  |e verfasserin  |4 aut 
700 1 |a Zhou, Yeqiang  |e verfasserin  |4 aut 
700 1 |a Liu, Yang  |e verfasserin  |4 aut 
700 1 |a Fu, Weili  |e verfasserin  |4 aut 
700 1 |a Xue, Jianxin  |e verfasserin  |4 aut 
700 1 |a Tan, Hong  |e verfasserin  |4 aut 
700 1 |a Ding, Mingming  |e verfasserin  |4 aut 
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