Assessing histological and molecular responses in goldfish exposed to copper sulfate : insights for sustainable aquatic health management
© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
| Veröffentlicht in: | Ecotoxicology (London, England). - 1992. - 34(2025), 8 vom: 03. Sept., Seite 1506-1515 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2025
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| Zugriff auf das übergeordnete Werk: | Ecotoxicology (London, England) |
| Schlagworte: | Journal Article CuSO4 Gene expression Goldfish Histopathology Copper Sulfate LRX7AJ16DT Water Pollutants, Chemical |
| Zusammenfassung: | © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. This study investigates the impact of copper sulfate (CuSO4) on goldfish (Carassius auratus), focusing on histological changes in gills, liver, and muscle tissues, as well as the expression patterns of key genes involved in muscle. Goldfish were exposed to three concentrations of CuSO4 (1.998 mg/L, 3.995 mg/L, and 5.993 mg/L) for 96 h. Histological examination revealed dose-dependent pathological changes, including gill epithelial proliferation, hepatocyte degeneration, and muscle necrosis. Gene expression analyses indicated significant upregulation of IGF-1 in the liver at high CuSO4 concentrations, while IGF-1 in muscle was consistently downregulated across all concentrations. MyoD gene expression was upregulated at the three tested concentrations, but it was the lowest at the highest concentration, whereas MURF2 was significantly upregulated in all experimental groups. These findings suggest that CuSO4 exposure disrupts normal histological structure in goldfish, highlighting the need for stringent environmental regulations to mitigate copper pollution in aquatic ecosystems. This study provides critical insights into the molecular and histopathological mechanisms underlying CuSO4 toxicity in fish, contributing to the development of evidence-based management strategies for aquatic conservation and aquaculture |
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| Beschreibung: | Date Completed 27.09.2025 Date Revised 27.09.2025 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1573-3017 |
| DOI: | 10.1007/s10646-025-02919-3 |