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250925s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202418838
|2 doi
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|a pubmed25n1579.xml
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|a eng
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|a Ortuño-Bernal, Alba
|e verfasserin
|4 aut
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|a Bi-Functional Topospecific Nanoparticles to Promote Immune-Tumor Cell Engagement as A New Immunotherapeutic Strategy
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|c 2025
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|a Text
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|a ƒaComputermedien
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|a Date Revised 24.09.2025
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2025 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.
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|a Cancer immunotherapy has emerged as a promising alternative approach, enabling the body's immune system to fight cancer. Cytotoxic T cells play a pivotal role in recognizing and eliminating tumor cells, and their effectiveness relies on establishing a physical interaction and efficient communication with cancer cells. However, this communication is often disrupted by immune escape mechanisms, allowing cancer progression. A versatile nanoplatform is developed to restore cellular connection using Janus mesoporous silica-Au nanoparticle (J-pHLIP-PD1), including specific binding sites on opposite faces for simultaneous binding to cancer cells and immune cells. The two differential surfaces on the nanoparticle allow orthogonal functionalization with the anti-PD-1 antibody that interacts with the PD-1 receptor in cytotoxic T cells on the gold face and the pH Low Insertion Peptide (pHLIP), which undergoes specific insertion into the tumor cell membrane on the silica face. J-pHLIP-PD1 nanoparticles effectively bind the surface of tumor cells and capture T cells, facilitating the formation of immune synapse-like structures that lead to reduced cancer cell viability in vitro, associated with immunogenic cell death signatures. The therapeutic potential of J-pHLIP-PD1 is also demonstrated in an in vivo metastatic melanoma model, where treatment with J-pHLIP-PD1 produces a significant decrease in metastatic burden and increases T cell presence. The Janus nanosystem represents an attractive platform that expands the toolbox of immune-engaging strategies, offering a flexible alternative to conventional immunotherapies that link immune and tumor cells, restoring cell-cell communication for cancer elimination
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|a Journal Article
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|a PD‐1
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|a communication
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|a immunotherapy
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|a nanoparticles
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|a pHLIP
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|a Clara-Trujillo, Sandra
|e verfasserin
|4 aut
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| 700 |
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|a Lucena-Sánchez, Elena
|e verfasserin
|4 aut
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|a Hicke, Francisco J
|e verfasserin
|4 aut
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|a Escudero, Andrea
|e verfasserin
|4 aut
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|a Pradana-López, Sandra
|e verfasserin
|4 aut
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|a Jiménez-Alduan, Nelia
|e verfasserin
|4 aut
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|a Díez, Paula
|e verfasserin
|4 aut
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|a García-Fernández, Alba
|e verfasserin
|4 aut
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|a Martínez-Máñez, Ramón
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2025) vom: 24. Sept., Seite e18838
|w (DE-627)NLM098206397
|x 1521-4095
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|g year:2025
|g day:24
|g month:09
|g pages:e18838
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|u http://dx.doi.org/10.1002/adma.202418838
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