Self-Evolving Discovery of Carrier Biomaterials with Ultra-Low Nonspecific Protein Adsorption for Single Cell Analysis

Self-Evolving Discovery of Carrier Biomaterials with Ultra-Low Nonspecific Protein Adsorption for Single Cell Analysis

© 2025 Wiley‐VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 37(2025), 37 vom: 10. Sept., Seite e2506243
Auteur principal: Hu, Songtao (Auteur)
Autres auteurs: Lu, Wenhui, Ding, Xijia, Xue, Yingying, Liu, Congcong, Xie, Tian, Deng, Yinjun, Li, Haoran, Gong, Zhuocheng, Xia, Yanming, He, Peishen, Zeng, Lingliao, Wang, Zhong, Jin, Jian, Luo, Zhi, Shi, Xi, Peng, Zhike, Xu, Tao, Cao, Xiaobao
Format: Article en ligne
Langue:English
Publié: 2025
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article artificial intelligence automated experiments biomaterials single‐cell analysis Biocompatible Materials Proteins
Description
Résumé:© 2025 Wiley‐VCH GmbH.
Carrier biomaterials used in single-cell analysis face a bottleneck in protein detection sensitivity, primarily attributed to elevated false positives caused by nonspecific protein adsorption. Toward carrier biomaterials with ultra-low nonspecific protein adsorption, a self-evolving discovery is developed to address the challenge of high-dimensional parameter spaces. Automation across nine self-developed or modified workstations is integrated to achieve a "can-do" capability, and develop a synergy-enhanced Bayesian optimization algorithm as the artificial intelligence brain to enable a "can-think" capability for small-data problems inherent to time-consuming biological experiments, thereby establishing a self-evolving discovery for carrier biomaterials. Through this approach, carrier biomaterials with an ultra-low nonspecific protein adsorption index of 0.2537 are successfully discovered, representing an over 80% decrease, while achieving a 10 000-fold reduction in experiment workload. Furthermore, the discovered biomaterials are fabricated into microfluidic-used carriers for protein-analysis applications, showing a 9-fold enhancement in detection sensitivity compared to conventional carriers. This is the very demonstration of a self-evolving discovery for carrier biomaterials, paving the way for advancements in single-cell protein analysis and further its integration with genomics and transcriptomics
Description:Date Completed 19.09.2025
Date Revised 19.09.2025
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202506243