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NLM392736071 |
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DE-627 |
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20250920232031.0 |
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cr uuu---uuuuu |
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250920s2025 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202502455
|2 doi
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|a pubmed25n1574.xml
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|a (DE-627)NLM392736071
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|a (NLM)40545861
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Miao, Dongtian
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Injectable Functional Porous Carbon-Loaded Hydrogel with Long-Term Retention and Synergistic Anti-Tumor Properties for Tumor Therapy
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 19.09.2025
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|a Date Revised 19.09.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 Wiley‐VCH GmbH.
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|a In situ therapies show significant promise for the treatment of unresectable tumors that lack tumor supply vessels. However, it remains a tremendous challenge to achieve precise delivery and sustained release of anti-tumor agents with synergistic anti-tumor efficacy. Here, a novel in situ injectable hydrogel (denoted as CFe/βCP+Cis hydrogel) has been designed by integrating β-CD-g-PEGMA (βCP) molecular brush hydrogel with functional carbon nanozyme (CFe) and cisplatin. The reversible gel network of βCP hydrogel and the rigid nanoscale architecture of CFe endow CFe/βCP+Cis hydrogel with properties conducive to injectability and long-term retention (more than 63 days). CFe and cisplatin mixed in hydrogel are both gradually released into the tumor tissue, facilitating the synergistic anti-tumor efficacy via ferroptosis and cytotoxicity. In addition, CFe/βCP hydrogel can reduce the M2-like/M1-like ratio of macrophages and promote the infiltration of CD8+ T cells in the tumor microenvironment to enhance anti-tumor immunity. As a result, the CFe/βCP+Cis hydrogel demonstrates significant potential for precise and sustained tumor treatment through chemodynamic therapy, chemotherapy, immunoregulation, and long-term retention properties
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|a Journal Article
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|a injectable hydrogel
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|a nanozyme
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|a polymer brush
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|a porous carbon
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|a tumor
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|a Carbon
|2 NLM
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|a 7440-44-0
|2 NLM
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|a Hydrogels
|2 NLM
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a Cisplatin
|2 NLM
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| 650 |
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7 |
|a Q20Q21Q62J
|2 NLM
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| 650 |
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7 |
|a Drug Carriers
|2 NLM
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| 700 |
1 |
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|a Luo, Rui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Xiusen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuanbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yi, Tan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Bingna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Rongkang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Dingcai
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 37(2025), 37 vom: 01. Sept., Seite e2502455
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
1 |
8 |
|g volume:37
|g year:2025
|g number:37
|g day:01
|g month:09
|g pages:e2502455
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| 856 |
4 |
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|u http://dx.doi.org/10.1002/adma.202502455
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 37
|j 2025
|e 37
|b 01
|c 09
|h e2502455
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