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250903s2025 xx |||||o 00| ||eng c |
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|a 10.1016/j.plantsci.2025.112730
|2 doi
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|a pubmed25n1564.xml
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|a eng
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|a Park, SangA
|e verfasserin
|4 aut
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|a RXLR effectors from Phytophthora infestans suppress host cell death and promote virulence via nuclear localization in Nicotiana benthamiana
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Revised 10.09.2025
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a Copyright © 2025 Elsevier B.V. All rights reserved.
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|a Phytophthora infestans, a destructive hemibiotrophic pathogen, relies on effector proteins to modulate host immunity and facilitate infection. However, the molecular mechanisms by which these effectors suppress host cell death during the biotrophic phase remain poorly understood. In this study, we identified three RXLR effectors-designated as Cell Death Suppressors (CDS1: Pi02860, CDS2: Pi04089, and CDS5: Pi06099)-that strongly suppress effector-triggered cell death in Nicotiana benthamiana. These CDSs are highly expressed during the early biotrophic phase and inhibit cell death triggered by diverse elicitors, including INF1, NPP1.1, Rpiblb2/Avrblb2, and Avr3a/R3a. Subcellular localization analysis revealed that the nuclear targeting is essential for their cell death suppressive activity. Functional assays demonstrated that CDS1 significantly enhances P. infestans virulence, while CDS2 and CDS5 contribute synergistically when co-expressed. Moreover, homologs of CDS1 from other Phytophthora species exhibited similar suppressive activity, despite lacking obvious sequence or structural features predictive of function. Our findings suggest that P. infestans utilizes a coordinated set of nuclear-targeting effectors to suppress host immunity during early colonization, offering new insights into pathogen strategies for immune evasion
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|a Journal Article
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|a Cell death
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|a Cell death inducer (CDI)
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|a Cell death suppressor (CDS)
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|a Hemibiotroph
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| 650 |
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|a Phytophthora infestans
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| 650 |
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|a RXLR effectors
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| 700 |
1 |
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|a Kim, Taewon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Soeui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Seo, Ye-Eun
|e verfasserin
|4 aut
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| 700 |
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|a In, Solhee
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Choi, Doil
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Joo Hyun
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Plant science : an international journal of experimental plant biology
|d 1985
|g 362(2025) vom: 23. Aug., Seite 112730
|w (DE-627)NLM098174193
|x 1873-2259
|7 nnas
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| 773 |
1 |
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|g volume:362
|g year:2025
|g day:23
|g month:08
|g pages:112730
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|u http://dx.doi.org/10.1016/j.plantsci.2025.112730
|3 Volltext
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