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250903s2025 xx |||||o 00| ||eng c |
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|a 10.1111/nph.70500
|2 doi
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|a pubmed25n1587.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Wu, Ya-Nan
|e verfasserin
|4 aut
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| 245 |
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|a Arabidopsis RabGDIs mediate Rab targeting and are crucial for male gametophytic function
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 02.10.2025
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|a Date Revised 02.10.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2025 The Author(s). New Phytologist © 2025 New Phytologist Foundation.
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|a Rab GTPases are key regulators of vesicular trafficking, not only switching between active and inactive forms but also cycling between donor/resident and target membranes, a process regulated by factors including guanine nucleotide dissociation inhibitors (RabGDIs), whose function is largely unknown in plants. By reverse genetic approaches, we demonstrate that Arabidopsis RabGDIs redundantly mediate male fertility such that the functional loss of RabGDIs compromises pollen development, germination, and directional growth of pollen tubes. By combining cellular and pharmacological approaches, we demonstrate that RabGDIs are critical for the targeting of Rab GTPases not only in secretory but also in vacuolar pathways. Vacuolar trafficking regulators such as Rab5 and Rab7 GTPases are mis-targeted to the apical plasma membrane of pollen tubes due to the functional loss of RabGDIs, hinting at a phylum-specific role of RabGDIs also in the initial targeting of Rab GTPases to their donor/resident membrane
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|a Journal Article
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|a cell polarity
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|a pollen germination
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|a pollen tube growth
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|a secretion
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|a vacuolar trafficking
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|a rab GTP-Binding Proteins
|2 NLM
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| 650 |
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|a EC 3.6.5.2
|2 NLM
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a Guanine Nucleotide Dissociation Inhibitors
|2 NLM
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| 700 |
1 |
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|a Yin, Gui-Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Jin-Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hao, Guang-Jiu
|e verfasserin
|4 aut
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| 700 |
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|a Li, Sha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 248(2025), 3 vom: 01. Okt., Seite 1255-1267
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnas
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| 773 |
1 |
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|g volume:248
|g year:2025
|g number:3
|g day:01
|g month:10
|g pages:1255-1267
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|u http://dx.doi.org/10.1111/nph.70500
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