|
|
|
|
| LEADER |
01000naa a22002652c 4500 |
| 001 |
NLM391656325 |
| 003 |
DE-627 |
| 005 |
20250903232431.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
250903s2025 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202509266
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1554.xml
|
| 035 |
|
|
|a (DE-627)NLM391656325
|
| 035 |
|
|
|a (NLM)40847694
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Hou, Shengxin
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Universal NIR-II-Emitting Unimolecular Micelles with Tailorable Pharmacokinetic and Optical Properties for Adaptive Imaging
|
| 264 |
|
1 |
|c 2025
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Revised 23.08.2025
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status Publisher
|
| 520 |
|
|
|a © 2025 Wiley‐VCH GmbH.
|
| 520 |
|
|
|a π-Conjugated fluorophores show great potential for NIR-II bio-imaging owing to their superior brightness and photostability, yet their clinical translation has been hindered by suboptimal pharmacokinetics. To address this issue, a strategy is developed to tailor the in vivo behavior of π-conjugate fluorophores by breaking π-π stacking in polymer brush-engineered unimolecular micelles. This approach marks a significant shift from traditional methods of tuning micelles, which rely on varying the hydrophilic-to-hydrophobic ratios and are often ineffective for π-conjugated systems due to the dominance of π-π interactions. By disrupting π-π interactions in the unimolecular micelles, pharmacokinetics and photophysical properties can be precisely controlled by systematically varying the molecular weight and composition of the polymer brushes. Accordingly, the blood circulation half-life can be adjusted across a 60-fold range, and fluorescence emissions are improved by 47-fold, facilitating adaptive fluorophore applications from kidney dysfunction detection to tumor imaging. Additionally, the engineered unimolecular micelles exhibit reduced nonspecific uptake and improved tumor targeting efficiency, resulting in a 5-fold higher tumor-to-liver ratio than conventional π-π stacked nano-aggregates. These findings offer a solid solution to the pharmacokinetic optimization issues and provide a new design principle for π-conjugated phototheranostic materials
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a NIR‐II imaging
|
| 650 |
|
4 |
|a pharmacokinetics
|
| 650 |
|
4 |
|a polymer brushes
|
| 650 |
|
4 |
|a unimolecular micelles
|
| 650 |
|
4 |
|a π‐conjugated fluorophores
|
| 700 |
1 |
|
|a Fan, GuiLing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gu, Ying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dong, Zhiyong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Mengying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Huang, Jia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Heng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Han, Liang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Qian, Hujun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a He, Feng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Qu, Songnan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Tian, Leilei
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2025) vom: 23. Aug., Seite e09266
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
|
| 773 |
1 |
8 |
|g year:2025
|g day:23
|g month:08
|g pages:e09266
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202509266
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|j 2025
|b 23
|c 08
|h e09266
|