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250802s2025 xx |||||o 00| ||eng c |
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|a 10.1016/j.plaphy.2025.110252
|2 doi
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|a pubmed25n1518.xml
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|a (DE-627)NLM39049965X
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|a (NLM)40749470
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|a (PII)S0981-9428(25)00780-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Zhang, Zhizhou
|e verfasserin
|4 aut
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|a Integrated omics reveals a SmGBF1-SmGDH3 model that facilitates the accumulation of salvianolic acid B under flooding
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|c 2025
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 01.08.2025
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a Copyright © 2025 Elsevier Masson SAS. All rights reserved.
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|a Salvianolic acid B, an active ingredient in Salvia miltiorrhiza, is renowned for its strong antioxidant capacity and significant medicinal value. As a rhizome herb, frequent flooding hinders its yield and quality. Recently, studies on the biosynthesis genes of salvianolic acid B have garnered considerable attention under abiotic stress. However, few reports focus on the impact of flooding on the biosynthesis of salvianolic acid B, and there is limited understanding of the potential mechanisms involved. This work found that the accumulation of salvianolic acid B under flooding stress was primarily due to increased ammonium nitrogen (NH4+). Among the numerous compounds, the substantial accumulation of primary metabolites captured our attention. Transcriptome sequencing further indicated that glutamate played a crucial role in responding to flooding stress. By integrating omics analysis, we constructed a co-expression network of S. miltiorrhiza under flooding stress and identified several candidate genes. The detailed analysis confirmed the role of the glutamate dehydrogenase gene (SmGDH3) in promoting the biosynthesis of salvianolic acid B in response to flooding/NH4+ signals. Subsequently, interaction analysis and transgenic assays revealed that SmGBF1 could bind to the promoter region of SmGDH3, enhancing its expression and ultimately leading to the accumulation of salvianolic acid B. Our results provide insights into the role of SmGBF1-SmGDH3 in the biosynthesis of salvianolic acid B, contributing to the improvement of the salvianolic acid B content of S. miltiorrhiza
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|a Journal Article
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|a Ammonium nitrogen
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|a Flooding stress
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|a Salvia miltiorrhiza
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|a Salvianolic acid B
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|a SmGBF1
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|a SmGDH3
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|a Shang, Yukun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Haomiao
|e verfasserin
|4 aut
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| 700 |
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|a Dai, SongJiang
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Yuanyuan
|e verfasserin
|4 aut
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| 700 |
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|a Deng, Xuexue
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Long
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Ruiwu
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Li
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Plant physiology and biochemistry : PPB
|d 1991
|g 228(2025) vom: 15. Juli, Seite 110252
|w (DE-627)NLM098178261
|x 1873-2690
|7 nnas
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| 773 |
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|g volume:228
|g year:2025
|g day:15
|g month:07
|g pages:110252
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|u http://dx.doi.org/10.1016/j.plaphy.2025.110252
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