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NLM389867195 |
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20250827235647.0 |
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cr uuu---uuuuu |
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250722s2025 xx |||||o 00| ||chi c |
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|a 10.3760/cma.j.cn112140-20241104-00788
|2 doi
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|a pubmed25n1545.xml
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|a (DE-627)NLM389867195
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|a (NLM)40692463
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhang, L L
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Analysis of 8 cases of primary mediastinal large B-cell lymphoma
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| 264 |
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1 |
|c 2025
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 20.08.2025
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|a Date Revised 20.08.2025
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To investigate the clinical features, pathologic characteristics, treatment and prognosis of primary mediastinal large B-cell lymphoma (PMBCL) in children. Methods: Clinical data including clinical manifestations, treatment, clinical efficacy of 8 cases of childhood PMBCL treated in Beijing Children's Hospital, Capital Medical University from March 2017 to February 2024 were collected retrospectively, the clinical characteristics and prognosis of them were summarized. Results: Among the 8 children, there were 5 males and 3 females. The age at the time of initial diagnosis was 11.0 (10.3, 13.5) years. The first clinical symptoms were cough (8 cases) and stridor (6 cases). The lesions most often involved the mediastinum (8 cases), lungs (5 cases, hilum more often), pericardium (5 cases), and pleura (4 cases). Extra thoracic invasion was present in 4 cases, 7 cases had huge tumor lesions and 7 cases were phase Ⅲ clinical stage. Except for 1 case who underwent surgical resection of the tumor, the remaining 7 cases were treated with DA-EPOCH+R (dose adjusted-etoposide+prednisone+vincristine+cyclo-phosphamide+doxorubicin+rituximab) chemotherapy. The follow-up time was 25.0 (10.5, 43.3) months, with 7 cases in complete and partial metabolism response, 1 case had disease progression. All 8 cases survived. Conclusions: PMBCL is most common in school-age boys and most of them present with huge mediastinal tumor focus. PMBCL expresses B-cell spectrum antigens and weakly expresses CD30.The application of DA-EPOCH+R is effective in the treatment of PMBCL in children
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|a English Abstract
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4 |
|a Journal Article
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| 650 |
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|a Rituximab
|2 NLM
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| 650 |
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7 |
|a 4F4X42SYQ6
|2 NLM
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| 650 |
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7 |
|a Doxorubicin
|2 NLM
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| 650 |
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7 |
|a 80168379AG
|2 NLM
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| 650 |
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7 |
|a Vincristine
|2 NLM
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| 650 |
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7 |
|a 5J49Q6B70F
|2 NLM
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| 650 |
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|a Prednisone
|2 NLM
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| 650 |
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7 |
|a VB0R961HZT
|2 NLM
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| 650 |
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7 |
|a Cyclophosphamide
|2 NLM
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| 650 |
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7 |
|a 8N3DW7272P
|2 NLM
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| 700 |
1 |
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|a Zhou, C J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Y H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duan, Y L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 63(2025), 8 vom: 02. Aug., Seite 901-905
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnas
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| 773 |
1 |
8 |
|g volume:63
|g year:2025
|g number:8
|g day:02
|g month:08
|g pages:901-905
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.3760/cma.j.cn112140-20241104-00788
|3 Volltext
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