ProBNP, cytokines, and the Nrf2/HO-1 signaling pathway A cross-sectional study on cardiovascular risk in rheumatoid arthritis

ProBNP, cytokines, and the Nrf2/HO-1 signaling pathway : A cross-sectional study on cardiovascular risk in rheumatoid arthritis

Copyright © 2025 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 278(2025) vom: 03. Juli, Seite 110541
1. Verfasser: Nobre, Christiane Aguiar (VerfasserIn)
Weitere Verfasser: Rodrigues, Carlos Ewerton Maia, Cavalcante, Natacha Xavier, Nascimento, Thácilla Siqueira Eugênio, Brayner, João Gabriel Marques, Sousa, Giovanna Azevedo, de Sousa, Nayara Alves, Ribeiro, Regislane Pinto, de Fiqueirêdo, Vanessa Maria Eufrásio, Paiva, Giulia Albuquerque, do Nascimento Costa, José Jackson, Goes, Paula, Chaves, Hellíada Vasconcelos, Mont'Alverne Parente Feijão, Ticiana, Bezerra, Mirna Marques
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Cardiovascular risk factors Cytokines Nrf2/HO-1 signaling pathway Oxidative stress ProBNP Rheumatoid arthritis NF-E2-Related Factor 2 NFE2L2 protein, human Heme Oxygenase-1 mehr... EC 1.14.14.18 Interleukin-6 HMOX1 protein, human RNA, Messenger
Beschreibung
Zusammenfassung:Copyright © 2025 Elsevier Inc. All rights reserved.
We evaluated associations between clinical/laboratory findings and serum cytokines, Nrf2/HO-1 pathway expression and cardiovascular risk in both RA patients and controls. Sixty RA patients and 60 controls were included in the study. Serum cytokine and proBNP levels were assessed by ELISA, while serum Nrf2 and HO-1 mRNA levels were quantified by qRT-PCR. The RA group (91.7 % women) and the control group (90 % women) were aged 52 ± 12 and 52 ± 13 years, respectively. ProBNP levels were higher in the RA group than in controls (p = 0.009). Nrf2 mRNA levels were higher (p < 0.001) and HO-1 mRNA levels were lower (p = 0.030) in the RA group than in controls. CDAI scores were significantly associated with serum IL-6 levels (p = 0.033). This study found a significant dysregulation in Nrf2/HO-1 pathway activity in RA patients, although without association with cardiovascular risk, RA-related clinical and laboratory variables. Moderate/high disease activity was positively associated with IL-6 levels
Beschreibung:Date Completed 16.07.2025
Date Revised 16.07.2025
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2025.110541