Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression

Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression

Copyright © 2025 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 278(2025) vom: 01. Juli, Seite 110533
1. Verfasser: Chen, Na (VerfasserIn)
Weitere Verfasser: Zhang, Leidan, Wang, Xinyue, He, Zhijiao, Wang, Di, Du, Juan, Deng, Meiju, Zhang, Mengyuan, Jiang, Meiqing, Wei, Yuqing, Zhao, Meng, Liu, Ying, Wang, Xiaolei, Zhao, Hongxin, Kong, Yaxian
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Foxp3 HIV Immune activation Immune regulation Natural killer T-like cells Forkhead Transcription Factors FOXP3 protein, human
Beschreibung
Zusammenfassung:Copyright © 2025 Elsevier Inc. All rights reserved.
Persistent immune activation is a key factor contributing to AIDS progression and non-AIDS-associated complications. NKT-like cells were found to exert immunosuppressive roles under some pathological situations by Foxp3 upregulation. Here, we found that Foxp3 was mainly expressed on CD4+NKT-like cells in untreated people living with HIV (PLWH) and the frequencies of Foxp3+CD4+NKT-like cells were correlated with HIV disease progression. Furthermore, the percentage of Foxp3+CD4+NKT-like cells was positively associated with immune activation and systematic inflammation. Foxp3+CD4+NKT-like cells might exert immunomodulatory effects by elevating the expression of TGF-β, IL-10, CD39, CD25, GITR, Ki67 and TIGIT. However, our analyses further identified Foxp3+CD4+NKT-like cells as a distinct subset that differed from conventional regulatory T cells. Notably, patients with higher baseline levels of Foxp3+CD4+NKT-like cells had a greater risk of poor immune reconstitution. These findings emphasized the importance of Foxp3+CD4+NKT-like cells during HIV infection and revealed its predictive role in immune reconstitution
Beschreibung:Date Completed 16.07.2025
Date Revised 16.07.2025
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2025.110533