Peripheral T-cell subset activation in NMDAR encephalitis Insights into pathogenesis and biomarker potential for disease monitoring

Peripheral T-cell subset activation in NMDAR encephalitis : Insights into pathogenesis and biomarker potential for disease monitoring

Copyright © 2025. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - (2025) vom: 25. Apr., Seite 110506
1. Verfasser: Wang, Minjin (VerfasserIn)
Weitere Verfasser: Wang, Jierui, Zhai, Jianzhao, He, Yangyi, Ma, Yuwen, Wang, Zhiyin, Ren, Yan, Ying, Binwu, Zhou, Dong, Li, Jinmei
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2025
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Anti-NMDAR encephalitis Immune activation Immune monitoring T-cell subsets
Beschreibung
Zusammenfassung:Copyright © 2025. Published by Elsevier Inc.
BACKGROUND: N-methyl-d-aspartate receptor encephalitis (NMDAR-E) is a severe autoimmune disorder characterized by neuropsychiatric symptoms and immune dysregulation ，involves T-cell dysregulation, but specific T-cell subset roles remain unclear. This study analyzed peripheral blood T-cell subsets as biomarkers for monitoring and severity prediction
METHODS: Peripheral blood samples from 32 NMDAR-E patients, 31 antibody-mediated encephalitis, 26 viral encephalitis patients, and 23 healthy controls were analyzed using flow cytometry. Key markers of T-cell activation and co-stimulation were assessed. Clinical outcomes were correlated with immune profiles to develop a predictive model
RESULTS: NMDAR-E patients showed elevated CD4+ T-cell activation, with increased CD28, CD38, and HLA-DR expression versus controls, indicating immune hyperactivation with compensatory regulation. The T-cell-based model predicted severe cases with high accuracy (AUC = 0.91)
CONCLUSION: CD4+ T-cell activation is central to NMDAR-E pathogenesis, highlighting diagnostic/therapeutic potential. Future studies must validate the model in larger cohorts and address peripheral blood analysis limitations
Beschreibung:Date Revised 27.04.2025
published: Print-Electronic
Citation Status Publisher
ISSN:1521-7035
DOI:10.1016/j.clim.2025.110506