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|a 10.1021/acs.langmuir.5c01044
|2 doi
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|a pubmed25n1397.xml
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|a (NLM)40266576
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|a DE-627
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|e rakwb
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|a eng
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|a Zhang, Jun
|e verfasserin
|4 aut
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|a Electrospinning Trilayer Dressing of PLA/ZnO with Controlled Released Profiles for Visible pH Monitoring and Effective Exudate Management
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|c 2025
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 06.05.2025
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|a Date Revised 06.05.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a To address persistent challenges in wound care, including exudate management, infection prevention, and healing monitoring, this study developed a multifunctional fiber dressing using electrospinning technology. The system integrates a patterned hydrophobic polylactic acid/zinc oxide (PLA/ZnO) inner layer providing antimicrobial protection and exudate drainage; a polyacrylonitrile/polydopamine (PAN/PDA) intermediate water transport layer enabling unidirectional exudate transfer; and an outer PAN-based functional membrane incorporating sodium polyacrylate (SPA), phenol red (PSP), and tetracycline hydrochloride (TCH) for controlled drug release and visual wound status monitoring. The comprehensive evaluation revealed exceptional performance: rapid exudate removal within 3.35 s, 96 h sustained antibacterial drug release (68.6% cumulative release), pH-responsive chromatic transition (yellow-to-red at pH 5-9), and significant antimicrobial efficacy against Escherichia coli and Staphylococcus aureus (inhibition zone diameters of 10 and 18 mm, respectively). The dressing exhibited a balance of mechanical strength (6.1 MPa tensile strength) and breathability (13.4 mm/s air permeability rate). By integrating three core functions─efficient exudate management, antimicrobial regulation, and intelligent healing monitoring─this multifunctional architecture demonstrates clinical applicability in postoperative care and chronic wound therapy
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|a Journal Article
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|a Polyesters
|2 NLM
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|a Zinc Oxide
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|a SOI2LOH54Z
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|a poly(lactide)
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|a 459TN2L5F5
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|a Anti-Bacterial Agents
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|a Polymers
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|a Tetracycline
|2 NLM
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|a F8VB5M810T
|2 NLM
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|a polyacrylonitrile
|2 NLM
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|a 25014-41-9
|2 NLM
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|a Acrylic Resins
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|a polydopamine
|2 NLM
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|a Indoles
|2 NLM
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| 700 |
1 |
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|a Hou, Chao
|e verfasserin
|4 aut
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1 |
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|a Yu, He
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Newton, Md All Amin
|e verfasserin
|4 aut
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|a Xin, Binjie
|e verfasserin
|4 aut
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| 700 |
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|a Li, Tingxiao
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 41(2025), 17 vom: 06. Mai, Seite 11192-11204
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
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|g volume:41
|g year:2025
|g number:17
|g day:06
|g month:05
|g pages:11192-11204
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|u http://dx.doi.org/10.1021/acs.langmuir.5c01044
|3 Volltext
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