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20250509113243.0 |
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250508s2025 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.4c04813
|2 doi
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|a pubmed25n1370.xml
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|a (DE-627)NLM386383553
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|a (NLM)40162629
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Koshani, Roya
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Zwitterionic Molecularly Imprinted Hairy Cellulose Nanocrystals Enable Selective Vancomycin Removal
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1 |
|c 2025
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 09.04.2025
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|a Date Revised 09.04.2025
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Access to free, off-target, and nontherapeutic doses of antibiotics is a key driving factor in the emergence of antimicrobial resistance (AMR). Intravenously (IV) administered vancomycin (VAN) is among the last-line antibiotics for treating infections caused by multidrug-resistant Gram-positive bacteria. A fraction of the total IV dose unwantedly reaches the gastrointestinal tract, driving AMR. Selective VAN removal from the complex intestinal fluid may reduce the probability of AMR emergence; however, it remains a significant challenge due to the competitive adsorption of other species. Here, we engineer novel VAN-imprinted polymerized zwitterionic hairy cellulose nanocrystals (ViPZ-HCNC) that selectively capture VAN with a removal capacity of ∼ 235 mg g-1 at an imprinting factor of ∼ 7.5. ViPZ-HCNC provide the first nanocellulose-based material with an excellent selectivity for VAN against lysine, lysozyme, and bovine serum albumin, which efficiently remove VAN from calcium ion-containing solutions and simulated intestinal fluids. Additionally, ViPZ-HCNC are not toxic against NIH/3T3 murine fibroblast cells. We envision that ViPZ-HCNC may pave the way for developing soft materials that selectively remove off-target VAN from a broad range of media, preventing VAN resistance evolution. This research is a step forward in addressing the long-lasting AMR challenge using a biobased platform
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|a Journal Article
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7 |
|a Cellulose
|2 NLM
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| 650 |
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7 |
|a 9004-34-6
|2 NLM
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| 650 |
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7 |
|a Vancomycin
|2 NLM
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| 650 |
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7 |
|a 6Q205EH1VU
|2 NLM
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| 650 |
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7 |
|a Anti-Bacterial Agents
|2 NLM
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| 700 |
1 |
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|a Yeh, Shang-Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kheirabadi, Sina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Zeming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Park, Min Ju
|e verfasserin
|4 aut
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| 700 |
1 |
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|a LeConey, Sean
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Read, Andrew F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sheikhi, Amir
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 41(2025), 13 vom: 08. Apr., Seite 8554-8564
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
8 |
|g volume:41
|g year:2025
|g number:13
|g day:08
|g month:04
|g pages:8554-8564
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| 856 |
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|u http://dx.doi.org/10.1021/acs.langmuir.4c04813
|3 Volltext
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|a GBV_ILN_350
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|a GBV_ILN_721
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|a AR
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|d 41
|j 2025
|e 13
|b 08
|c 04
|h 8554-8564
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